pharm 1

  1. What are the Five Pure Opioid Agonists??
    • 1. Morphine
    • 2. Fentanyl
    • 3. Meperidine
    • 4. Methadone
    • 5. Oxymorphone
  2. What are the Therapuetic Uses of Pure Opioids??
    Moderate to severe pain

    Acute chronic pain

    Pain not relieved by nonpharmacologic measures or NSAIDS

    Pain of a myocardial infarction (MI)
  3. What are the Physiologic Actions of Pure Opioids??
    Agonist to mu and kappa receptors

    ↓ release of substance P (modulates pain perception)

    Mimics actions of endogenous opioid peptides
  4. What are the Respiratory Side Effects of Pure Opioids
    Depression, cough suppression
  5. What are the Cardiovascular Side Effects of Pure Opioids
    Low Blood Pressure
  6. What are the Gastrointestinal Side Effects of Pure Opioids
    Nausea, Vomitting, Constipation, biliary colic
  7. What are the Genitourinary Side Effects of Pure Opioids
    Urinary retention
  8. What are the Neurologic Side Effects of Pure Opioids
    Sedation, euphoria, increased intraocular pressure, miosis, toxicity
  9. What are the interactions with Pure Opiods Agonists
    • CNS depressents
    • Anticholinergics
    • tricyclic antidepressants
    • MAOIs
    • antihypertensives
  10. What do you want to monitor with Pure Opioid Agonists
    • Pain level
    • Heart Rate
    • Blood Pressure
    • Respirations
  11. What is Meperidine's other name
  12. Meperidine is

    Short half life, multiple drug interactions

    Metabolite: Normeperidine

    Biliary or pancreatic disease

    Dosing for rigors
  13. Another name for Mehtadone is
  14. Methadone is a Pure Opioid that is for
    • Pain relief
    • cheap
    • treatment for opioid addicts
  15. What Pure Opioid Agonists is a treatment for opoid addicts ??
    Methadone (Dolphine)
  16. What does Methadone do for drug addicts
    blocks euphoria from heroin and morphine

    long half life (12-30 hrs): prevents withdrawal

    cross tolerance with heroin and morphine

    people are on it for decades
  17. What opioid is used for an MI
  18. What do Mu receptors promote

  19. What do Kappa receptors promote
    analgesia, some sedation, some GI motility,

    no Respiratory depression and euphoria as with pure agonist

    Monitor pt carefully
  20. Agonist-Antagonist Opioid
    Pentazocine (Talwin)
  21. What are the Other 3 Agonist-Antagonist Opioids
    • Butorphanol (Stadol),
    • Nalbuphine (Nubain),
    • Buprenorphine (Buprenex)
  22. Therapeutic Uses of Agonist-Antagonist Opioid
    Relieves mild to moderate pain
  23. What is a Pure Opioid Antagonist
    Nalaxone (pure antagonist)
  24. What does Nalaxone do
    • Rapidly displaces all receptor bound opioid molecules (pure
    • agonist)
  25. What is the Dosing and Routes of Nalaxone
    Dosing: 0.4 mg to 2 mg for adults

    Routes IV, IM, SC
  26. Adverse effects of Nalaxone
    Dysphoria, vomiting, diarrhea, agitation
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