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Production of antibodies and lymphocytes after exposure to an antigen.
acquired immunity
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Mass of lymphatic tissue in the nasopharynx.
adenoids
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Protein produced by B cell lymphocytes to destroy antigens.
antibody
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Substance that the body recognizes as foreign; evokes an immune response. Most antigens are proteins or protein fragments found on the surface of bacteria, viruses, or organ transplant tissue cells.
antigen
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Lymph nodes in the armpit (underarm).
axillary nodes
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Lymphocyte that originates in the bone marrow and transforms into a plasma cell to secrete antibodies. The B refers to the bursa of Fabricius, an organ in birds in which B cell differentiation and growth were first noted to occur.
B cell (B lymphocyte)
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Lymph nodes in the neck region.
cervical nodes
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Proteins in the blood that help antibodies and T cells kill their target.
complement system
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Proteins that aid and regulate the immune response. Examples are interferons and interleukins.
cytokines
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T lymphocyte that directly kills foreign cells (CD8+ cell or T8 cell)
cytotoxic T cell
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Specialized macrophage that digests foreign cells and helps B and T cells to mark antigens for destruction.
dendritic cell
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Lymphocyte that aids B cells and cytotoxic T cells in recognizing antigens and stimulating antibody production; also called CD4+ cell or T4 cell)
helper T cell
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Body's ability to resist foreign organisms and toxins. This includes natural immunity and acquired immunity.
immunity
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Antibodies (gamma globulins) such as IgA, IgE, IgG, IgM, and IgD that are secreted by plasma cells in response to the presence of an antigenb.
immunoglobulins
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Use of immune cells, antibodies, or vaccines to treat or prevent disease.
immunotheraphy
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Lymph nodes in the groin region.
inguinal nodes
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Proteins (cytokines) secreted by T cells to aid and regulate the immune response.
interferons
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Proteins (cytokines) that stimulate the growth of B and T lymphocytes.
interleukins
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Fluid in the spaces between cells. This fluid becomes lymph when it enters lymph capillaries.
interstitial fluid
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Thin, watery fluid found within lymphatic vessels and collected from tissues throughout the body. Latin lympha means clear spring water.
lymph
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Tiniest lympatic vessels.
lymph capillaries
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Lymph nodes, spleen, and thymus gland.
lymphoid organs
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A collection of stationary solid lymphatic tissue along lymph vessels.
lymph node
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Carrier of lymph throughout the body; lymphatic vessels empty lymph into veins in the upper part of the chest.
lymph vessel
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Large phagocyte found in lymph nodes and other tissues of the body.
macrophage
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Lymph nodes in the area between the lungs in the thoracic (chest) cavity.
mediastinal nodes
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Anbtibody produced in a laboratory to attack antigens and to destroy cells. It is useful in immunotherapy.
monoclonal antibody
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Protection that an individual inherits to fight infection.
natural immunity
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Lymphocyte that produces and secretes antibodies. It originates from B lymphocytes.
plasma cell
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Large lymphatic vessel in the chest that receives lymph from the upper right part of the body.
right lymphatic duct
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Organ near the stomach that produces, stores, and eliminates blood cells.
spleen
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What kind of immunity?
No prior exposure to antigens
Neutrophils
Monocytes and macrophages
natural immunity
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What kind of immunity?
Antibodies produced after an infection
Vaccination
Antitoxins
Immunoglobulins
Maternal antibodies
T and B cells
acquired immunity
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Lymphocyte that inhibits the activity of B and T lymphocytes. Also called a Treg (regulatory T cell).
suppressor T cell
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Lymphocyte that originates in the bone marrow but matures in the thymus gland; it acts directly on antigens to destroy them or produce chemicals (cytokines) such as interferons and interleukins that are toxic to antigens.
T cell (T lymphocyte)
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The ability of T lymphocytes to recognize and accept the body's own antigens as "self" or friendly. Once tolerance is established, the immune system will not react against the body.
tolerance
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Large lymphatic vessel in the chest that receives lymph from below the diaphragm and from the left side of the body above the diaphragm; it empties the lymph into veins in the upper chest.
thoracic duct
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Organ in the mediastinum that conditions T lymphocytes to react to foreign cells and aids in the immune response.
thymus gland
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Mass of lymphatic tissue in the back of the oropharynx.
tonsils
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Poison; a protein produced by certain bacteria, animals, or plants
toxin
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Exposure of an individual to a foreign protein (antigen) that provokes an immune response. The response will destroy anyt cell that possesses the antigen on its surface and will protect against infection.
vaccination
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Weakened or killed microorganisms, toxins, or other proteins given to induce immunity to infection or disease.
vaccine
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Severe combined immunodeficiency disease (SCID)
Affected infants are born with a deficiency of B cells and T cells, resulting in a lack of immunity.
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Acquired immunodeficiency syndrome (AIDS)
Group of clinical signs and symptoms associated with suppression of the immune system and marked by opportunistic infections, secondary neoplasmas, and neurologic proglems.
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Human immunodeficiency virus (HIV)
HIV destroys helper T cells (also known as CD4+ cells, containing the CD4 protein antigen). This disrupts the immune response, allowing infections to occur.
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Opportunistic infections
Infectious diseases associated with AIDS.
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Kaposi sarcoma
A cancer arising from the lining cells of capillaries that produce dark purplish skin nodules.
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Wasting syndrome
Marked by weight loss and decrease in muscular strength, appetite, and mental activity.
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HAART (Highly Active AntiRetroviral Therapy)
Use of combinations of protease inhibitors (neldinavir, amprenavir) and RTIs
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Abnormal hypersensitivity acquired by exposure to an antigen.
allergy
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Atopic
related to atopy, a hypersensitivity or allergic state arising from an inherited predisposition
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Malignant tumor of lymph nodes and lymph tissue.
lymphoma
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Malignant tumor of lymphoid tissue in the spleen and lymph nodes, characterized by lymphadenopathy, splenomegaly, fever, weakness, and loss of weight and appetitie. Diagnosis is often made by identifying a malignant cell (Reed-Sternberg cell) in the lymph nodes.
Hodgkin disease
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Follicular lymphoma (composed of collections of small lymphocytes in a follicle or nodule arrangement) and large cell lymphoma (composed of large lymphocytes that infiltrate nodes and tissues diffusely).
Non-Hodgkin lymphomas. These are mostly B cell lymphomas and rarely T cell malignancies.
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Malignant tumor of bone marrow cells.
multiple myeloma
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Malignant tumor of the thymus gland
thymoma
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Substance capable of causing a specific hypersensitivity reaction in the body; a type of antigen.
allergen
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Exaggerated or unusual hypersensitivity to foreign protein or other substance.
anaphylaxis
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Hypersensitive or allergic state involving an inherited predisposition. From the Greek word atopia, which means strangeness.
atopy
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Helper T cells that carry the CD4 protein antigen on their surface.
CD4+ cells. HIV binds to CD4 and infects and kills T cells bearing this protein. AIDS patients have an inadequate number of CD4+ cells.
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Infectious diseases associated with AIDS.
opportunistic infections
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Drug that treats AIDS by blocking the production of protease, a proteolytic enzyme that helps create new viral pieces for HIV.
protease inhibitor
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Drug that treats AIDS by blocking reverse transcriptase, an enzyme needed to make copies of HIV.
reverse transcriptase inhibitor (RTI)
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Weight loss, decrease in muscular strength, appetite, and mental activity; associated with AIDS
wasting syndrome
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Measures the number of CD4+ T cells (helper T cells) in the bloodstream of patients with AIDS.
CD4+ cell count
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Screening test to detect anti-HIV antibodies in the bloodstream.
ELISA
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Test that separates immunoglobulins (IgA, IgE, IgG, IgM, IgD)
immunoelectrophoresis
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Measurement of the amount of AIDS virus (HIV) in the bloodstream
viral load test
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CD8+ cell
cytotoxic T cell. same as T8 cell
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CD4+ cell
helper T cell. same as T4 cell
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Regulatory T cell (suppressor T cell)
Treg
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Chronic, disabling disease in which the body produces antibodies against its own tissues. Examples are rheumatoid arthritis and lupus erythematosus.
autoimmune disease
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Protein (antibody produced by plasma cells) that acts to protect the body by destroying antigens.
immunoglobulin
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Suppression (stopping) of the immune response.
Immunosuppression
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Formation of lymph.
lymphopoiesis
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Swelling of tissue due to accumulation of lymph fluid in intercellular spaces.
lymphedema
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Deficiency of lymphocytes in the blood.
lymphocytopenia
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Abnormal condition of increase in lymphocytes.
lymphocytosis
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Derived from lymph tissue.
lymphoid
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A syndrome marked by splenomegaly (associated with anemia, leukopenia and thrombocytopenia).
hypersplenism
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An exaggerated hypersensitivity reaction to foreign proteins.
anaphylaxis
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Intense allergic reaction (such as asthma) influenced
by hereditary tendency or predisposition.
atopy
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Specific test to detect presence of anti-HIV
antibodies in the bloodstream.
Western blot
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