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Additional chemical compenent, such as a inorganic ion or a complex organic or metalloorganic molec that may be required by an enzyme
cofactor
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complex organic or metalloorganic molec
coenzyme
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Coenzyme or metal ion that's very tightly bound or covalently bound to the enzyme protein
prosthetic group
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A complete, catalytically active enzyme together w/its bound coenzyme and/or metal ions
holoenzyme
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protein portion of a holoenzyme
apoenzyme or apoprotein
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Energy derived from enzyme-substrate interaction
Binding energy
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The ability of an enzyme to discriminate b/w a substrate and competing molec
specificity
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When enzyme-substrate interactions replace most or all of the H bonds b/w the substrate and water
Desolvation
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Concentration of substrate that leads to half-maximal velocity
Km
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Max # of enzymatic rxns catalyzed per sec
Kcat
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Type of enzymes which have increased or decreased catalytic activity in response to certain signals, thereby altering the rate of metabolic sequences.
Regulatory enzymes
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Enzymes which function through reversible, noncovalent binding of regulatory compounds, which are generally small metabolites or cofactors
Allosteric enzymes
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Regulatory compounds that are generally small metabolites or cofactors
Allosteric modulators or allosteric effectors
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Regulatory enzymes for which substrate and modulator are identical are called ___
homotropic
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When the modulator is a molecule other than the substrate, the enzyme is called ____
heterotropic
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Enzymes which attach phosphoryl groups to specific aa residues of a protein
Protein kinases
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Enzymes which remove phosphoryl groups
Protein phosphatases
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Inactive precursor of a consensus sequence which is cleaved to form the active enzyme
Zymogen (or general term is proproteins or proenzymes)
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