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what are thrombocytes?
platelets, cytoplasmic fragments
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what do thrombocytes look like?
- non-nucleated
- smaller than RBC
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where are thrombocytes made?
in the bone marrow
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what is the function of thrombocytes?
hemostasis (starts clotting process)
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how are thrombocytes produced in the bone marrow?
megakaryoblast divides and turns into promegakaryoctyes. promegakaryocytes divide and turns into megakaryocyte, the platelets then break off
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how long are platelets lifespan in circulation?
about 10 days
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define thrombocytosis
greater than normal thrombocytes
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define thrombocytopenia
less than normal thrombocytes
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define thrombocytopathia
not able to function correctly in clotting mechanism
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what is the normal range for thrombocytes?
- 200,00 - 500,000/ul
- clinical signs once below 50,000/ul
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what are the clinical signs of an animal with too little thrombocytes
- unable to clot blood
- spontaneous mucosal bleeding (epistaxis & hematuria, melena & ocular hemorrhage, gingival bleeding, bruising/echymoses, petechial hemorrhages
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how to estimate the total number of platelets
- count the total number of platelets in 10 fields
- multiply by 1500
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what are the mechanisms of thrombocytopenia?
- decreased production
- increased destruction
- consumption
- sequestration (can't get out of the spleen)
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what are shift platelets?
bigger than normal platelets
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what causes shift platelets?
breaking off early due to an increased demand
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