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Neuropathies

  1. Causes of Weakness
    Originating in Nerve Roots
    • 1. Disc Herniation
    • 2. Metabolic Radiculopathy eg. DM
  2. Causes of Weakness
    Originating in Peripheral Nerves
    • 1. Metabolic Disorders
    • 2. Inflammatory Disorders
    • 3. Trauma
  3. Metabolic Disorders causing Neuropathy
    • 1. Diabetes Mellitus
    • 2. Renal Disease- Uraemia
    • 3. Vitamin Deficience eg. Vit B12
  4. Immune Mediated disorders
    causing Neuropathy
    • 1. GBS -Guillain-Barre syndrome (acute polyneuropathy)
    • 2. CIDP- Chronic inflammatory demyelinating polyneuropathy
    • 3. Vasculitis- Lupus, Polyarteritis
    • 4. Sarcoid
    • 5. Sjorgen's
  5. Infectious Disease causing Neuropathy
    • 1. Herpes Zoster
    • 2. Leprosy
    • 3. Lyme Disease
    • 4. HIV
  6. Nutritional Disorders causing Neuropathy
    • 1. Vitamin deficiency especially:
    • -Thiamine
    • -Niacin
    • -B12
  7. Toxicity causing Neuropathy
    • 1. Alcohol
    • 2. Lead
    • 3. Arsnic
    • 4. Gold
    • 5. Insectisides
  8. Drugs causing Neuropathy
    • 1. Isoniazid
    • 2. Vincristine
    • 3. Cisplatinum
    • 4. Metronidazole
    • 5. Amiodarone
    • 6. Phenytoin
  9. Hereditary Disroders causing Neuropathy
    • 1. Charcot-Marie-Tooth Disease (motor sensory)
    • 2. HNPP - Hereditary Neuropathy with predisposition to pressure palsy
    • 3. Familial Brachial Plexopathy
    • 4. Familial Amyloidosis
    • 5. MND
  10. Aquired Disorders Causing Neuropathy
    • 1. Metaboic
    • 2. Immune
    • 3. Neoplastic
    • 4. Infection
    • 5. Nutritional
    • 6. Toxic
    • 7. Drugs
  11. Neuropathic Disorders that produce Asummetric/ Focal Weakness
    • 1. MND
    • 2. Radiculopathy (cervical or lumbosacral)
    • 3. Plexopathy (Brachial or Lumbosacral)
    • 4. Mononeuropathy Multiplex
    • 5. Compressive/ Entrapment Mononeuropathies
  12. Radiculopathies
    (Effect Nerve Root)
    • 1. Root Compression
    • - Osteoarthritis
    • - Herniated Disc
    • 2. Herpes Zoster
    • 3. Meningeal Carinomatosis and Lymphomatosis
  13. Plexopathies
    (affect Nerves, Blood vessels and Lymph Vessels)
    • 1. Neoplastic Infiltration
    • 2. Diabetic Radiculopexopathy (esp Lumbrosacral)
    • 3. Familial Brachial Plexopathy
    • 4. HNPP
  14. Mononeuropathy Multiplex due to
    • 1. Malignant Infiltration - Carcinoma or lymphoma
    • 2. Vasculitis
    • 3. Connective Tissue Disease (RA, LUPUS, )
    • 4. Sarcoidosis
    • 5. DM
    • 6. Infections
    • - Leprosy
    • - Herpes Zoster
    • - HIV
    • -Lyme Disease
    • 7. HNPP
  15. Compressive/ Entrapment Mononeuropathies
    • 1. Median Neuropathy
    • 2. Ulnar Neuropathy
    • 3. Peroneal Neuropathy
  16. Symmetric
    Prox + Distal
    Weakness + Sensory Loss
    • 1. GBS -Guillain- Barre Synd
    • 2. CIDP- Chronic Inflammatory Demyelinating Polyradiculopathy
  17. Symmetric
    Distal
    Sensory Loss +/- Weakness
    • 1. Metabolic Disorders
    • 2. Drugs/ Toxins
    • 3. Hereditar (eg. CMT)
  18. Asymmetric
    Distal
    Weakness + Sensory loss
    • 1. Multiple Nerves-
    • a. Vasculitis
    • 2. HNPP
    • 3. CIDP
    • 4. Infectious

    • 2. Single nerve/root
    • a. Vasculitis
    • b. Compressive Mononeuropathy and Radiculopathy
  19. Asymmetric
    Proximal + Distal
    Weakness + Sensory loss
    • Polyradiculopathy/ Plexopathies:
    • 1. Diabetes Mellitus
    • 2. Neoplasia
    • 3. Herediatry (HNPP)
  20. Asymmetric
    Distal
    Weakness (no sensory)
    • 1. With UMN signs
    • a. Motor Neuron Disease

    • 2. No UMN signs
    • a. Progressive muscular atrophy
    • b. Multifocal motor neuropathy
    • c. Multifocal acquired motor axonopathy (MAMA)
    • d. Juvenile monomelic amyotrophy
  21. Symmetric
    Sensory loss (+/- distal weakness)
    Distal Hyporeflexia (aareflexia)
    UMN Signs
    • 1. B12 deficiency
    • 2. Hereditary
    • 3. Cervical Spondylosis
  22. Symmetric
    Proximal + Distal
    Weakness (No sensory loss)
    Spinal muscular atrophy
  23. Symmetric
    Distal
    Weakness (No sensory loss)
    Herediary Motor Neuropathy
  24. Asymmetric Propioceptive loss
    No weakness
    (sensory neuronopathy)
    • 1. Cancer (paraneoplastic)
    • 2. Sjogren's Synd
    • 3. Vit B6 toxicity
    • 4. Vit E defeciency
    • 5 Cisplatinum
    • 6. HIV related
    • 7 Idiopathic
  25. Autonomic Dysfunct
    • 1. Diabetes Mellitus
    • 2. GBS
    • 3. Porphyria
    • 4. HIV related autonomic neuropathy
    • 5. Vincristine-induced
    • 6. Amyloidosis
Author
Rosie435
ID
129003
Card Set
Neuropathies
Description
Neuropathy
Updated

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