-
gp 120/41
HIV gp120-DCSIGN, then CD4
-
parotitis, orchitis
mumps
-
Ab-Ag compexes
Parvo B19, rubella, Hep B, Dengue
-
Demyelination
JC (polyoma), PML, intranuc inclusions
-
-
-
-
-
acute hemorrhagic conjunctivitis
enterovirus 70
-
aseptic meningitis
mumps, echo, coxsackie, entero 71
-
gastroenteritis
rota, calici (Noro, Sapo), astro, adeno 40 and 41
-
segmented RNA
reo, bunya, orthomyxo
-
Reye's
aspirin to kids for flu, VZV
-
SARS
SARS-CoV, severe LRTI
-
JAK/STAT
antiviral signaling, blocked by RSV, measles, mumps, parainfluenza
-
food poisoning, epidemic GE
norovirus
-
CXCR4 CCR5
chemokine receptors CXCR4 and CCR5 (macrophage) HIV binds
-
tegument
herpes, regulatory, proteins
-
villi atrophy, blunting
rotavirus, enterocytes replaced with secretory cell
-
-
HA and N on same protein
mumps (very antigenic)
-
parainfluenza
1 and 2 not bad, 3 is bad
-
measles
rash goes face>trunk>limbs
-
amantadine/rimantidine
A only: M2 channel blocked (uncoating blocked), resistance
-
Oseltamivir (Tamiflu) and Zanamivir (Relenza)
A and B: block N (virion release)
-
8 segments
influenza type B
-
7 segments
influenza type C
-
HA and N on different spikes
influenza
-
NS1
inhibits production of cellular interferon mRNA; influenza
-
sialic acid
what HA attaches to in order to enter cell
-
M2 protein
influenza; ion channel to acidify virus so it can uncoat in the host cell
-
replication in nucleus
influenza
-
-
FluMist
live vaccine; nasal spray, influenza
-
spherical, corona of spikes
Coronavirus
-
translation into two polypeptides
coronavirus
-
predisposition to otitis medis, sinusitis, worsens asthma
coronavirus
-
hypoxia, pneumonia, respiratory distress syndrome
SARS-CoV
-
diffuse edema and hypoxia
corona virus
-
binds ACE-2 to disregulate fluid
coronavirus
-
possesses H and cell fusing
measles (rubeola)
-
-
maculo-papular rash
measles
-
subacute sclerosing panencephalitis
measles
-
worsened by Vitamin A deficiency
measles
-
blocks JAK/STAT of IFN pathway
measles, HPIV, mumps
-
glycoprotein and cell fusing proteins
RSV
-
mutlinucleated giant cell formation
RSV
-
palivizumab/synagis humanized monoclonal Ab to fusion protein
RSV
-
-
HA and N on same spike
HPIV, mumps
-
-
nebulizer as rx
for croup; HPIV
-
myalgia, anorexia, malaise
mumps
-
-
-
orchitis/oophoritis
mumps
-
-
myocarditis, pericarditis
mumps
-
-
VP1-3 attaches to ICAM-1
rhinovirus
-
synthesized as one large polypeptide
rhinovirus
-
capsid w/ VP1-4 proteins
enterovirus
-
transient viremia
enterovirus
-
destruction motor neurons
poliovirus
-
inactivates IF for cellular mRNA
polivirus
-
skin and mucous membranes
group A coxsackievirus
-
meninges, motor neurons
group B coxsackievirus
-
herpangia, aseptic meningitis, hand foot and mouth disease, cardiopathy, acute hemorrhagic conjunctivitis
group A coxsackie
-
pleurodynia, myocarditis of newborn, hepatitis, aseptic meningitis, myocarditis/pericarditis in adults, insulin dependent diabetes
group B coxsackie
-
cleaves ELF-4
coxsackie virus
-
epidemic of non bacterial gastroenteritis
norwalk virus
-
cruise ships
norwalk virus
-
abdominal cramping, watery diarrhea
norwalk virus
-
can survive outside host
norwalk virus
-
dsRNA in 11 segments
rotavirus (reoviridea)
-
wheel with spokes
rotavirus
-
icosahedral capsid with two layers
rotavirus
-
attaches to beta adrenergic receptor
rotavirus
-
NSP4
from rotavirus; acts as enterotoxin and induces watery diarrhea or enters ENS via Ca dependent transepithelial secretion
-
duodenum; blunted epithelial cells at tips of villi
rotavirus
-
rotashield
rotavirus; live vaccine
-
rotateq
rotavirus; live vaccine against 5 serotypes
-
sapovirus
human gastroenteritis; contaminated foods, self limiting
-
ssRNA, star like
astrovirus; human gastroenteritis
-
heme oxygenase
heme degradation to biliverdin
-
biliverdin reductase
biliverdin conversion to bilirubin
-
pale stools, dark urine
hepatitis (all of them)
-
obstructive jaundice
due to gallstones and inflammatory damage from viral hep
-
alkaline phosphatase
detects bile obstruction and infiltrative diseases of liver
-
gamma glutamyl transpeptidase
minor liver dysfunction; recent alcohol abuse
-
incubation of 3-4 weeks
Hep A
-
Twinrix vaccine
HAV + HBV, active
-
-
-
-
-
X gene
HBV; X protein; act viral RNA TC
-
virons, spheres, filaments
particles of HBV
-
HBeAg
HBV; from infected cells to blood, indicator of transmissibility
-
Hepadnovirus
only viruses to produce genomic DNA via rt w/mRNA as a template
-
fecal oral hep
HAV (non env)
-
high incidence in Asia (hep)
HBV; high incidence hepatocellular carcinomas
-
-
-
-
-
complete recovery HBV test results
-
chronic carrier HBV test results
-
Pegasys
HBV rx for chronic carriers, alpha IFN
-
Lamivudine (Epivir)
HBV rx, inhib rt of HIV and inhib DNA pol of HBV
-
Adefovir (Hepsera)
HBV rx, analog AMP, inhib DNA pol
-
Entecavir (Baraclude)
HBV rx, deoxyguanine analog, inhib DNA pol in HBV
-
Telbivudine (Tyzeka)
HBV rx, thymidine analgog, inhib DNA pol for HBV
-
Recombivax vaccine
HBsAg from recombinant DNA in yeasts
-
HBIG
high titer HBsAb, immediate, passive immunity to needlestick exposures
-
hypervariable region in glycoproteins
HCV
-
liver and HCV
increased replication of the Flavivirus because liver specific miRNA
-
-
Hep and p53
HCV; blocks p53 synthesis...apoptosis hell!
-
-
cirrhosis of chronic HCV
common indicator of liver transplantation
-
cryoglobulinemia
HCV Ag/Ab
-
-
chronic HCV rx
pegasys + ribavirin
-
HIV + HCV
HAART administered
-
Defective virus
HDV; cannot replicate alone because cannot make its own env prot (uses HBV env prot)
-
-
superinfected
previously infected by HBV and then infected by HDV
-
waterborne enteric hep
HEV; common everywhere but Europe and US
-
eye, respiratory, urinary, GI inflammatory diseases
Adenovirus
-
Fiber, Hexon, Penton
adenovirus
-
attachment to cellular integrins
adenovirus via fiber/HA
-
self assembly in nucleus
viral structural proteins of adenovirus
-
E1A
inhibits p53 and pRb; adenovirus
-
adenovirus 3,4,7,21
respiratory disease
-
adenovirus 8,9
epidemic keratoconjunctivitis (corneal opacities)
-
adenovirus 11,21
hemorrhagic cystitis
-
adenovirus 40,41
infant gastroenteritis
-
adenoidal and tonsillar pathology
latent adenovirus infection
-
shell vial assay
adenovirus lab technique
-
monovalent, live vaccine
adenovirus 4,7,21; military only, in enteric coated capsule to protect from GI degradation
-
E1B and E3
adenovirus, block CTL mediated apoptosis and expression of MHC 1
-
E1A
adenovirus, increases viral survival
-
integrins on epithelial squamous cells via L1 viral capsid
HPV
-
basal, undifferentiated cells of epidermis
HPV early genes
-
differentiated cells of dermis
HPV late genes, mature virions
-
E6 and E7
HPV causes overexpression...cancer
-
E2
HPV; controls E6 and E7 when episomal (non carcinogenic)
-
p53
normally regulates apoptotic Bax and cell progression via P21C1P; Destroyed by E6 HPV
-
pocket proteins
pRb, p107, p103; destroyed by E7 HPV; release E2Fs when attacked by HPV
-
koliocytes
cytoplasmic vacuoles; HPV
-
HPV 1-4
skin, plantar warts
-
HPV 6-11
condylomata, acuminata, resp/laryngo in kids
-
HPV 16-18
cervix, penis, anus
-
-
sialic acid
rx for plantar and genital warts
-
imiquimod
immune response modulators for HPV
-
gardasil vaccine
against L1 of 6, 11, 16, 18
-
cervavix vaccine
L1 of 16, 18, 31, 45
-
VP1 capsid protein
polyomavirus
-
-
BK virus
polyomavirus; shedding in urine, graft loss in immunosuppressed renal transplants
-
JC
polyomavirus; multifocal leukoencephalopathy because oligo and astrocyte destruction
-
T cell leukemia/lymphoma
HTLV
-
Tax
HTLV; transcription activator, required for malignant transformation of T cells, activates IL-2 and its receptor (T cell growth)
-
Rex
HTLV; viral mRNA processing and exit to cytoplasm
-
gp46, gp 21
envelope proteins for HTLV
-
lymphadenopathy, hepatosplenomegaly, lytic bone lesions, hypercalcemia
ATL
-
flower shaped nucleus
ATL, HAM
-
gait disturbance, weak limbs, no bowel/bladder control
HAM
-
-
vpr
HIV; virus from cytoplasm to nucleus
-
-
-
-
env
HIV; gp 160 (120 + 41)
-
Type B HIV
mononuclear cells, anal sex
-
Type E HIV
female genital tract, vaginal se
-
tat
HIV; increases gene transcription
-
nef
HIV; decreases MHC 1 expression
-
Rev
HIV; later mRNA from nucleus to cytoplasm
-
V3 loop
on gp120 of HIV; most immunogenic region
-
CXCR4
co receptor for HIV on T cell
-
CCR5
co-receptor for HIV on macrophages
-
maculopapular not on palms and soles
HIV early, acute stage
-
antigen receptor complex
fevers, fatigue, weight loss, lymphadenopathy
-
oraquick
finger prick test for HIV, needs Western Blot for confirmation
-
zidovudine, azidothymidine, retrovir
inhibit HIV replication via proviral DNA synthesis; hematoxicity side effects
-
lamivudine/ emtricitabine
same as ZDV but well tolerated
-
Nevirapine, Efavirenz
NNRTI, Stevens-Johnson syndrome
-
Saquinavir, ritonavir, nelfinavir, indinavir
PI, buffalo hump, lipodystrophy
-
enfuvirtide
fusion inhibitor, blocks gp41
-
maraviroc
fusion inhibitor, inhibits IN
-
PEP low risk regimen
lamivudine and zidovidine
-
PEP high risk regimen
lamivudine + zidovidine + lopinavir/ritonavir
-
trimethoprim
prevent OI of pneumonia
-
fluconazole
prevent OI of meningitis
-
ganciclovir
prevent OI of retinitis from CMV
-
antifungals
prevent OI of thrush
-
spastic paraparesis, bladder dysfunction, keratoconjunctivitis, ureitis, arthritis, polymyositis
HAM
-
brick shaped particles
pox
-
specific and cross reacting Ab
pox virus
-
viroreceptors, INF resistance
pox
-
benign epidermal tumor
molluscipoxvirus
-
posterior auricular lymphadenopathy
Rubella
-
erythroblast P Ag
receptor for B19 (parvovirus)
-
VP1,2,3; resistance to pH, solvents, temperature
parvovirus
-
hairpin palindromes
parvovirus
-
erythema infectiosum, aplastic anemia
parvovirus
-
bullet shaped capsid
Rhabdovirus (rabies)
-
uses Ach receptor
rhabdovirus
-
hydrophobia
throat swallowing, in rhabdovirus
-
limbic system
furious rabies
-
-
-
black vomit
yellow fever (flavivirus)
-
pleural effusion
dengue hemorrhagic fever (flavivirus)
-
3 segmented, ss negative RNA genome
bunyavirus
-
severe thrombocytopenia
ebola (filovirus)
-
2 segmented ss negative RNA
arenavirus
-
budding of nuclear membrane
herpes viruses
-
LATs
latency associated transcripts; in herpes; noncoding RNAs that suppress viral replication
-
heparin sulfate and nectin
used for entry of HSV1/2
-
-
VP16
viral protein, herpes; in conjuction with host TF, activates viral transcription of IE proteins
-
thymidine kinase
in host cells of HSV1/2 infected cells; drug target
-
trigeminal ganglia
place of latency for HSV-1
-
lumbar/sacral ganglia
place of latency for HSV-2
-
-
erythema multiforme
bulls eye lesions in HSV1/2
-
Stevens-Johnson
severe erythema multiforme of HSV1/2; involves desquamating skin lesions
-
Reye's syndrome
from taking Aspirin, related to flu and VZV; encephalitis and liver degeneration
-
opthalmic of trigeminal
zoster
-
varivax
live vaccine to prevent VZV
-
zostavax
live vaccine to prevent zoster
-
most common cause congenital abnormalities
CMV (herpes)
-
cytomegalic inclusion disease
infants with CMV
-
heterophilnegative mononucleosis
CMV
-
retinitis, intractable colitis
CMV
-
viral pp65
used in IF assay of CMV
-
C3 complement
activated when EBV (herpes) infects B lymphocytes
-
non specific heterophilnegative mononucleosis
EBV (herpes)
-
infectious mononucleosis
EBV
-
oral hairy leukoplasia
EBV
-
lymphoproliferative disease
EBV
-
nasopharyngeal carcinoma
EBV
-
-
-
xanthem subitum, roseola infantum
herpes 6 and 7
|
|