Heme/Onc MKSAP

  1. Treatment for aplastic anemia that 80% of patients respond to.
    Immunosupressive: antityhmocyte glubulin, corticosteroids, cyclosporine.
  2. First line treatment for very young patients with aplastic anemia.
    Hematopoetic stem cell transplant (higher mortality in older patients)
  3. Infection associated with pure red cell aplasia
    Parvovirus B19
  4. Treatment when cause of pure red cell aplasia is unknown.
    Immunosupressive: corticosteroids, cyclophosphamide, or cyclosporine.
  5. Charasteristics of Fanconi anemia.
    Pancytopenia, hypocellular bone marrow, short stature, cafe-au-lait spots, thumb abnormalities.
  6. Drugs causing aplastic anemia.
    ACEI's, antibiotics, amio, H2-blockers, HCTZ, NSAIDs, PTU
  7. Therapy that may induce complete remission for myelodysplastic syndromes.
    Azacitidine and decitabine (pyrimidine nucleoside agents).
  8. What does Lenalidomide specificially treat?
    5q-syndrome (most become transfusion dependend)
  9. Treatment for young patients with myelodysplastic syndrome.
    Stem cell transplant from an HLA-matched sibling donor.
Card Set
Heme/Onc MKSAP
Key points