-
MAOI's
- MAO-A for 5-HT(seratonin)
- MAO-B for dopamine
-
tricyclic antidepressants
inhibit the high affinity uptake of NE and 5-HT(seratonin)
-
SSRI
inhibit the high affinity uptake of 5-HT(seratonin) ONLY
-
cocaine and ritalin
- inhibit the uptake of dopamine, NE and 5-HT
- - cocaine- short half-life
- - ritalin- long half-life
-
amphetamine
releases dopamine, 5-HT and NE from nerve terminals
-
barbituates
- - stimulate GABA-A receptor (Cl- channel that opens in response to GABA
- - suicide risk
-
benzodiazepines
- - sensitize the GABA-A receptor
- - NO suicide risk
- - eg, Valium
-
eicosanoid syndrome
- tumor that over produces 5-HT
-
Pentose Phosphate p/w
- - G-6-PDH is main enzyme
- - main products NADPH and Ribulose-5-Phosphate
- -G6PDH inhibited by NADPH
-
Transketolase
- - activity is a sign of thiamine status
- - part of the nonoxidative branch of the PPP along with transaldolase
-
Polyol p/w
-make fructose from glucose for use in seminal vesicles
-
incretins
- augment insulin secretion by 3-4 times
-
GLP-1
- - glucagon like polypeptide
- - increases satiety
- - increases insulin secretion
- - decreases gastric emptying
-
GLUT 1
- - brain glucose transporter
- - NON insulin dependent
-
GLUT 2
- - hepatocytes (liver)
- - NON insulin dependent
-
GLUT 4
- - CM, SkM and adipose tissue
- - insulin dependent
-
HbA1C
- - goal < 7.0%
- - glycosylated Hb- an indicator of BG over last 120 days
-
leptin
- - Th1 stimulation, Th2 inhibition
- - decreases food intake, bone formation
- - increases energy expienditure (beta-ox), SNS activity
- - uses JAK-STAT p/w
- - increases inflammation (TNF and IL-6)
-
adiponectin
- - increases glucose uptake
- - decreases gluconeogenisis
- - increases beta-oxidation
- - prevents plaque formation
- - reduces inflammation (IL-10 IL-1RA)
-
TNF gamma
- - induces insulin resistance
- - promotes lipolysis
- - down regulates adiponectin
- - up regulates IL-6 and IL1 (proinflammatory)
-
IL-6
- - increases adipolysis
- - increases FA oxidation
- - increases serum glucose
- - down regulates IRS-1
- - down regulates adiponectin
-
curare
- blocks Nm receptors in the muscles
-
Atropine and scopalamine
- block M receptors
-
rate limiter in catecholamine synthesis
- tyrosine hydroxylase
-(DA->NE->Epi)
-
rate limiter in catecholamine and indoleamine inactivation
- uptake on CT's by high affinity Na cotransporter
-
aa NT's
- excitatory- glu and asp
- inhibitory- gly
-
glutamate decoarboxylase
- - glutamate--> GABA
- - deficiency==> seizures
- - coez= B6
|
|
