Pathophys Test 2

ABO antigens (p.24)

Located on membranes of many cells of the body (RBCs, epithelial cells, endothelial cells)
ABO system – extremely important in blood transfusions and organ transplantation
- Antigens’ wide distribution
- Presence of preformed antigens
- Individuals normally have antibodies to ABO antigens NOT found in their own tissue cells or RBCs
- - Result of cross-reactions with carbohydrate determinants of environmental bacteria
- - When one comes in contact with bacterial antigens (or proteins), he or she forms antibodies that react to “similar” antigens on RBCs
Rh Antigens
- There are about 25 components of Rh blood group, but only cde/CDE alleles play significant role in Rh incompatibility reactions
- Unlike ABO system, antibodies are not formed until an Rh-negative person receives blood from Rh-positive donor
What is the purpose of Rh-immune globulins like Rhogam or Gamulin Rh – meaning how do they prevent sensitization of mother’s immune system against fetal RBCs? (p.24)
- Anti-D-globulins given on exposure to Rh-positive blood or prophylactically
- Anti-D antibodies cover (mask) antigenic sites on fetal RBCs and are then removed by scavenger cells
- May prevent sensitization of mother’s immune system to fetal Rh-antigens
Review blood group compatibility (p.24)

Author

cgordon05

12754

Card Set

Pathophys Test 2

Description

ABO Antigens and Antibodies

Updated

2010-04-01T02:56:57Z

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