Pharm Anti-neoplastic

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Cyclosporine
- Protects against rejections from organ transplants
- does not induce bone marrow depression
Cyclophosphamide
- Ankylating agent of both purine and pyrimide bases of DNA
- Tx - CLL
Cisplatin's Toxicities

Nephro & Ototoxicity
Methotrexate
- Antimetabolite of folic acid (folic acid analog): (-) tetrahydrofolate synthesis by (-) dihydrofolate reductase
- Tx for ALL and Psoriasis
Leucovorin Rescue

Can block/reduce Methotrexate = increase folic acid via reduced folate
Bleomycin Toxicity's

pneumonities & pulmonary fibrosis
Azathiorine
- Used in organ transplantation = kidney allografts
- Allopurinol can increase its activity by (-) its biotransformation to xanthine oxidase
MOPP
- Chemotherapy used in the tx of Hodgkin's Disease
- M = Mechlorethamine - nitrogen mustard
- O = Oncovin (Vincristine) - prevents microtubule assembly
- P = Procarbazine
- P = Prednisone - glucocorticoid, including apoptosis
Tamoxifen
- (-) estrogen receptor
- Tx of breast tumors can see associated endometrial Ca
Flutamide
- Antiandrogenic
- Used w/ Leuprolide (LH-RH analog)
- Tx prostatic Ca
Megestrol
- (-) progesterone receptor
- Tx endometrial ca
Fluoxymesterone
- Androgenic steroid
- tx mammary ca in postmenopausal woman
Brain Tumor tx
- Lomustine
- Carmustine - causes pulmonary fibrosis
Streptozocin
- Attaches to Beta cells
- tx of pancreatic insulinomas
Cytarabine (AraC)
- Pyrimidine analog
- DOC for AML
Dactinomycin

Used for Wilms tumor and rhabdomyosarcoma
Etoposide

Used for Oat cell Ca
Paclitaxel

Used for ovarian Ca
Amifostine

Can decrease nephrotoxicity due to chronic use of Cisplatin

Author

nicstrain

12737

Card Set

Pharm Anti-neoplastic

Description

Anit-neoplastic drugs

Updated

2010-04-06T02:40:36Z

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