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Reminder: You may have to scroll up on some of the answers! And please let me know if you find any mistakes!
Thank you!
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GP Cocci Clusters (Pathogens)
- Staphylococcus
- - S. aureus
- - S. epidermidis
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GP Pairs and Chains (Pathogens)
- Streptococcus
- - S. pneuomoniae
- - S. pyogenes (GAS)
- - S. agalactiae (GBS)
- Enterococcus
- - E. faecALIS
- - E. faesCIUM (tougher and stronger of the two)
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GP Bacilli (Pathogens)
Listeria monocytogenes
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GN Cocci Pairs and Chains (Pathogens)
- Neisseria sp.
- Moraxella catarrhalis
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GN Bacilli
- Enterobacteriaceae:
- - Morganella sp.
- - Escherichiia coli
- - Klebsiella sp.
- - Serratia sp.
- - Proteus sp.
- - Enterobacter sp.
- - Citrobacter sp.
- "MEK SPEC"
- Pseudomonads
- - Pseudomonas aeruginosa
- - Acinetobacter sp.
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GN Coccobacilli football-shaped (Pathogens)
Haemohilius sp.
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Atypicals
- Legionella pneumophila
- Chlamydia sp.
- Mycoplasma pneumoniae
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Anarobes
- GP: Clostridium sp.
- GN: Bacteroides sp.
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Is s. aureus a jock or a nerd?
- Both!
- MSSA (Some B-lactams will work)
- MRSA (No B-lactams will work)
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What is the type and shape of staph aureus?
GP cocci clusters
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95% of s. aureus produces what?
A beta-lactamase called "penicillnase"
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Methicillin resistance is attributed to what?
mecA gene
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What are the 2 major categories of MRSA?
- HA-MRSA (Healthcare associated)
- - Epidemiology: 37% skin/soft tissue
- CA-MRSA (Community associated)
- - Epidemiology: 74% skin/skin structure
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What are some RELIABLE Anti-MRSA antibiotics?
- Vancomycin
- Daptomycin
- Ceftaroline
- Linezolid (PO)
- Tigecycline
- Telavancine
- TMP/SMX (PO)
"Van Da Chef Likes Tiger Tails & TeMPura"
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What are some LESS RELIABLE Anti-MRSA antibiotics?
"the Docs at the CLINic is not reliable"
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Infrequently used Anti-MRSA antibiotics:
- Quinupristin
- Dalfopristin
- Chloramphenicol
- Nitrofurantoin
- Rifampin
"Quinn Da Colored Ninja 'infrequently uses' Reefer"
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What is the type and shape of s. epidermidis? AKA?
GP cocci clusters
- AKA:
- - Coagulase-negative Staph (CoNS)
- - Staph no aureus (SNA)
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Are CoNS or SNA's virulent or pathogenic?
- No, they're NERDs.
- - Production of biofilm
- - Multi-drug resistant
- - Treat with RELIABLE anti-MRSA
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What are some common staph epidermidis infections?
- Catheter-related bloodstream/UTI
- Skin/skin structure infections (cellulitis)
- Prosthetic joint infection
- Prosthetic valve endocarditis
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What is the type and shape of strep pneuomoniae? AKA?
GP cocci pairs/chains
AKA: pneumococcus
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Is pneumococcus virulent and pathogenic?
- Yes, it's a JOCK! (mostly)
- - Encapsulated
But it's becoming a NERD as well!
- Resistance starting to emerge against:
- - Macrolides
- - B-lactams
- - FQ
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Staph pneumoniae is the most common cause of:
- Community acquired pneumonia
- Bacterial meningitis
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What types of infections can s. pnuemoniae cause?
- Sinusitis
- Otitus media
- Skin/skin structure infections (not common)
- Much much more
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What is the type and shape of strep pyogenes? AKA?
GP cocci pairs/chains
- AKA:
- - Group A Strep (GAS)
- - Flesh eating bacteria
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Is Group A Strep virulent and pathogenic?
- Yes, it's a JOCK!
- - Toxin producer
- - Causes tissue necrosis
Still sensitive to PCN
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Strep pyogenes is a common cause of:
- Strep throat
- Skin/skin structure infection
- TOXIC SHOCK SYNDROME
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What is the type and shape of strep agalactiae? AKA?
GP cocci pair/chains
AKA: Group G Strep (GBS)
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GBS is normally colonized where?
- Normal vaginal flora in 40% of women.
- - Tested during pregnancy
- - Treated continuously during delivery
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What's the most common cause of neonatal sepsis?
- Strep agalactiae
- - Can cause many other infections but usually only in immunocompromised patients
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What is the type and shape of enterococcus faecalis and faceium? And where is it normally colonized?
GP cocci pairs/chains
Normal flora of GI tract, skin and mouth
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T/F: Faecalis is more resistant than faecium.
- False!
- Think faecaLIS = LESS
- VRE is more often faecium.
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Enterococcus faecali and faecium is common cause of:
- Nosocomial (hospital acquired)
- - Bacteremia
- - Endocarditis
- - UTI
- - Wound infections
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T/F: Listeria monocytogenes is a GN cocci.
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Define listeriosis.
An infection caused by eating contaminated food
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People who are at risk of listeriosis should avoid:
- Hot dogs
- Soft cheeses
- Pate or meat spreads
- Smoked seafood
- Raw (UNpasteurized mild)
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Clinical manifestations of listeriosis:
- Healthy adults:
- - usually asymptomatic or mild flu-like disease
- Pregnant women, newborns, immunocompromised:
- - Range from mild flu-like symptoms to meningitis and/or meningeoncephalitis
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T/F: Listeria monocytogenes infections of the fetus is extremely uncommon and can lead to abortion, stillbirth, or delivery of an acutely ill infant.
- False!
- It's extremely COMMON.
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GN Rod General Rules: Common bacteria in???
GI tract
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GN Rod General Rules: Just about any antibiotic with GN activity will have intrinsic activity except (fill in the blank).
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GN Rod General Rules: Antibiotic susceptibilities vary widely dependent upon (fill in the blank).
resistance mechanisms
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GN Rod General Rules: First line = ??? Exceptions?
- First line = "narrowest spectrum" B-lactam
- Ex: Don't use IMIPENEM when CEPHALEXIN is sensitive.
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GN Rod General Rules: Second line = ???
- Aminoglycoside
- Tetracycline
- Fluoroquinolone
- Macrolide
"All Time Favorite Mistress" (Get it? Second chick?)
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What is the type and shape of neisseria sp? NERD or JOCK?
GN cocci (diplococci) pairs/chains
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Neisseria meningitidis is the (blank 1) common pathogen in bacterial meningitis, and it passed by exchange of (blank 2).
- 1. second most
- 2. saliva or respiratory secretions
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T/F: N. gonorrhoeae is more dangerous than n. meningitidis.
- False!
- Meningitidis is the more dangerous of the two.
- - Vaccine available
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Small % of population is colonized with n. meningitidis in (blank).
sinus cavity
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N. gonorrhoeae, AKA (blank 1) and is normal flora in (blank 2)
- 1. gonococcus
- 2. It is NOT normal flora.
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N. gonorrhoeae is passed by???
- Direct MUCOSAL contact during sexual interaction.
- - Can also cause NEONATAL infections if mother is infected.
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What is the type and shape for moraxella catarrhalis? It's also a common cause of what?
GN cocci (diplococci) pairs/chains
- Common cause of URTIs
- - Otitis media (3rd most common cause)
- - Laryngitis, sinusitis, bronchitis
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Maraxella catarrhalis is also a (LESS COMMON) cause of:
- Pneumonia
- Bacteremia
- Meningitis
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T/F: E. coli and klebsiella are BOTH GN rods and are the two MOST common bacteria in the GI tract.
- False!
- Yes, they are both GN rods but...
- B. FRAGILIS is the most common bacteria in the GI tract.
E. coli is the most common AEROBIC bacteria in the GI tract.
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T/F: E. coli is the MOST common pathogen for community and hospital-associated.
True!
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Because of their high prevalence in/on our body, e. coli and klebsiella causes multiple other infections such as:
- Bacteremia
- Intra-abdominal
- Wound
- Healthcare associated pneumonia.
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E. coli 0157 is a common cause of (blank).
- Food-borne illness
- - NON-harmful in cattle, but TOXIC in humans.
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E. Coli and klebsiella the are the two MOST common producers of what?
ESBL: Extended-Spectrum Beta-Lactamase
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The common producers of ampC B-lactamase:
- Serratia
- Proteus
- Pseudomonas
- Acinetobacter
- Citrobacter
- Enterobacter
- Moranella
Because many of these pathogens are multi-drug resistant, susceptibility testing is required.
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AmpC B-lactamase deactivates ALL B-lactams except:
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Antibiotics with (blank) coverage will have intrinsic activity against SPACE-M pathogens.
GN
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Pseudomonas aeruginosa is a (blank 1), found in soil or water outside of the (blank).is a common cause of (blank 2). Normal flora in (blank 3).
- 1. GN rod
- 2. Found in soil of water outside the hospital
- 3. Not normal flora
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Pseudomonas aeruginosa is a common cause of (blank).
- Healthcare-associated:
- - Pneumonia (second leading pathogen to MRSA
- - Blood stream infections
- - Wound infection
- - Post-op infection
- - UTI
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Pseudomonas aeruginosa colonization can happen (blank).
- Hospitalized pts:
- - Chronic ventilator pts
- - Indwelling catheters or g-tubes
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T/F: Pseudomonas aeruginosa is BOTH a NERD and a JOCK.
True!
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Pseudomonas aeruginosa active PCN:
- Piperacillin/tazobactam
- Ticarcillin/clavulanic
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Pseudomonas aeruginosa active Cephalosporins:
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Pseudomonas aeruginosa active Carbapenem:
- Imipenem/cilastatin
- Meropenem
- Poripenem
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Pseudomonas aeruginosa active Monobactam:
Aztreonam
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Pseudomonas aeruginosa active Aminoglycosides:
- Gentamicin
- Tobramycin
- Amikacin
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Pseudomonas aeruginosa active FQ:
- Ciprofloxicin
- Levofloxacin
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Pseudomonas aeruginosa active Polymixin:
Colistin
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Acinetobacter sp. is a GN (blank 1), but can become (blank 2) shaped in stationary phase. NERD or Jock?
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Acinetobacter sp. is mostly found in (blank)
- Hospital in/on equipment
- - Can live for days to weeks on inanimate objects
- - Infection control is best defense against Acinetobacter.
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Acinetobacter has a HIGH mortality rate due:
- Severity of illness of pt, NOT due to pathogen virulence.
- Infected pt was already faily sick or immunocompromised.
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Acinetobacter sp. causes:
- Pneumonia (mostly in ventilated pts)
- Infection in open wound
- Line infection
-Pt must have pre-existing break in natural immuninity
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H. influenzae is a (type and shape?) bacteria and usually causes (blank) in children. NERD or JOCK?
GN coccobacilli ( football-shaped)
- Causes (usually in children):
- CAP
- Meningitis
- Sinusitis
- Otitis media
- Conjunctivitis
It's a JOCK!
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T/F: H. Influenzae is NOT encapsulated.
- False!
- It IS encapsulated.
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Legionella pneumophila, Chlamydia sp. and Mycoplasma pneumoniae are what type of bacteria, and what do they normally cause?
Atypical
- All causes REPIRATORY TRACT infections.
- -Constitue to about 25% of CAP pathogens.
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Legionella pneumophila is also known as (blank 1) and is usually found in (blank 2).
- 1. Pontiac Fever and Legionnaires' disease.
- 2. Usually found in water, dispersed via AC vents.
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Clostridium sp. is a (type and shape?) of bacteria.
GP rod ANaerobe, spore former
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What causes botulism?
- Clostridium botulinum
- Associated with honey and home canned food.
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Botulism can cause (blank 1) And is treated with what antibiotic?
1. paralysis from toxin.
- That is why there are NO antibiotics for it.
- Need ANTITOXIN - Trivalent (A, B, E)
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Tetanus is cause by what?
- Clostridium tetani
- Associated with puncture wounds
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Tenanus can cause (blank) and is treated with (blank).
- Causes repeated synapse firing from toxins resulting in:
- Muscle spasms
- Hyperreflexia
- Seizures
- Treated with:
- Penicillin
- Surgery
- Muscle relaxants
- Booster shot Q 10 years
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Gas gangrene is caused by (blank).
Clostridium perfringens
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Gas gangrene causes (blank 1) and is treated with (blank 2).
1. Produces toxin and ACIDIC ENZYMES that causes TISSUE NECROSIS.
- 2. Treated with:
- Antitoxin
- Surgery
- Hyperbaric chamber
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CDAD is caused (Blank)
Clostridium difficile (duh!)
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