-
What is retinol a precursor for?
-
Retinoic acid is an endogenous ligand for _________________ and _____________________________.
- Retinoic acid receptors (RARs)
- Retinoic acid receptors (RXRs)
-
When retinoic acid and RARs make a complex they form a _______________________ factor.
transcription
-
What is the function of the RA/RAR ligand/receptor complex?
- binds directly to DNA gene promoter regions
- Regulates gene transcirption (by regulating translation of mRNA into protein)
-
What are the characteristics of 1st & 2nd generation retinoids?
- Flexible backbones
- May bind several retinoid receptors
- Greater side effects
-
What are teh characteristics of 3rd generation retinoids?
- More rings= less flexible
- Interacts with fewer retinoid receptors
- Mild side effect profile
-
What is the MOA of Tretinoin (Retin A)?
- Binds to RARs
- Exfoliative (Inc Mitosis- dec. cell adhesion, exfoliative, dessquamation, keratolysis)
- Inflammation (Inc. Prostaglandid E2- vasodilation, intracell edema)
-
What are the side effects of Tretinoin?
- Irritation, Erythema, Peeling, Dryness
- "worsening of acne"
- Photosensitivity
- Anti-wrinkle effect- vasodilation and inc. collagen
-
What kind of acne is Tretinoin used for?
mild to moderate
-
How do you use Tretinoin?
- Apply to affected area once daily at bedtime (can start every other night)
- Increase strength only after 4-6 weeks of lowest concentration
- Full effect in 3-4 months
-
When do you see the full effect of TRetinoin?
3-4 months
-
What is the Preg Category of Tretinoin?
C
-
In what ages can Tretinoin be used?
greater than 12ys
-
Which retinoid is a derivative of napthoic acid?
- Adapalene (Differin)
- similiar to 3rd generation retinoids
-
What is the MOA of Adapalene?
- binds to nuclear retinoic acid receptors
- uncharacteristic anti-inflammatory actions
-
What kind of acne is adapalene used to treat?
mild to moderate
-
How do you use adapalene?
apply once daily at bedtime
-
What is the pregnancy cetegory of adapalene?
C
-
In what ages can adapalene be used?
greater than 12
-
What retinoid will least likely have an acne flare up on inititiation?
adapalene
-
What is the active form of Tazarotene (Tazorac)?
taxarotenic acid
-
What generation retinoid is tazarotene is most similiar to?
- third
- milder side effect profile
-
What is the MOA of tazarotene?
- Binds to smaller # of RARs
- Exfolliative-- differentiation--blocks orthinine decarboxylase
- Kerotylitic
- Anti-Inflammatory
-
What kind acne is tazarotene used for?
mild to moderate
-
How do you apply tazarotene?
once at bedtime
-
What is the Preg Category of tazarotene?
X
-
In what ages can tazarotene be used?
greater than 12ys
|
|
