the ability to estabilish a secondary neiplam at a new site
Carcinoma in situ is :
preinvasive and a glandular or epithelial lesion
Known routes of metastais include:
continuous extension
lympathic spread
bloodstream dissemination
Tumor suppressor genes are:
normall genes that regulate growth and development
genes that produce proteins that inhibit cellular division
Which is not involved in metastasis?
initial establishment
Oncogenic viruses are:
capable of transforming a normal cell into a concerous cell
The p53 gene:
enabes cells to cope with DNA damage
blocks the proliferation of cells that have suffered carcinogenic mutations
mutations are the most common genetic lesion in human cancer
mutations disable an emergency brake on cell proliferation
Local invasive factors include all except:
increase cellular adhesions
The sequence of carcinogensis is :
ionizing radiation, caretaker gene activity, and point mutations
An adenoma is :
benign
a gladular epithelial neoplasm
Carcinoma:
arise from epithelial tissure
Sacrcomas:
arise from connective tissue
How are cancer cells classified:
by anaplasia or loss of differentiation
by autonomy or independence from normal cellular controls
The three main genetic mechanisms have a role in human carcinogenesis:
1. mutation of the genes resulting in hyperactivity of growth related gene products such as oncogenes
2. mutation of genes resulting in loss or inactivity of gene products that normally would inhibit growth such as tummor suppressor genes
3. mutation of genes resulting in overexpression of products that prevent normal cell death or apotosis thus resulting in allowed continued growth of tumor
Successful Metasitasis includes:
survival in circulation
attachment and grwoth
induction of aniogenesis at a favorable distant site are required.