Patho Chapter 5

  1. Inflammation:
    destroys injurious agents
  2. Inflammatory microcirculation changes involve all of the following except:
    days to develop
  3. A phagocytes role begins with an infalmmatory response. The sequence for phagocytosis is :
    margination, diapedesis, recognition. adherence, ingestion, fusion, with lyosomes inside the phagocyte, destruction of the target.
  4. Chemotactiv factors for phagocytes include all of the following except:
    plasminogen activator
  5. Which is not a local manifstation of inflammation?
  6. Complement is :
    a series of proteins in the blood
  7. Diapedesis is the process in which:
    neutrophils migrate from teh bloodstream to an injured tissue site
  8. Interferon:
    prevents viruses from infecting healthy host cells.
  9. The complement system can be activated by the :
    • binding of complement 1 to a complement binding site of an antibody
    • components of other plasma protein systems
    • the binding of complement 3 to bacteria
  10. which is not a systemic manifestation of inflammation?
  11. The inflammatory response :
    minimizes injury and promotes healing
  12. Scar tissue:
    nonfunctional collagenous and fibrotic tissue
  13. Repair involves processes that :
    • fill the wound
    • cover or seal the wound
    • shrink the wound
  14. Swelling during acute inflammation is caused by :
    fluid and cellular exudation
  15. Which is not released from mast cells during degranulation?
  16. Chronic inflammation is characterized by:
    lymphocytic and macrophagic infiltration
  17. Which is synthesized by mast cells?
  18. Primary intention healing:
    • involves collagen synthesis
    • requires littel wound contractions
    • requires little would epithlialization
  19. Interleukins:
    • provide messages between leukocytes
    • are produced in response to tissure injury
    • stimulate cells to produce antiviral substances
    • increase antibody production and popultion of T cells
  20. Eosinophils:
    • control vascular effects of serotonin and histamine by lysosomal mediators
    • have lysosomal protein and can dissolve ethe surgece membranes of parasites
  21. The two types of human defense:
    • Innate resistence which includes natural barriers and inflammatory response
    • Adaptive *aquired immune system
  22. Mast Cells:
    • most important activator of the inflammatory response
    • initiates inflammation by releasing biochemical mediators (histamine or chemotatic) from preformed cytoplasmic franules and synthesising other mediators (leukotrienes and prostaglandis) in response to a stimulus.
  23. Histamine:
    is a major vasoactive amine released from mast cells. It causes constriction of vasuclar smooth muscles, dialation of capillaries and retraction of endothelial cells lining the capillaries, which increase vasucalr permeability
  24. Cells involved in inflammatory process:
    • neutrophils
    • monocytes
    • macrophages
    • eosinophils
    • natural killer cells and platelets
  25. Local Manifestations of inflammations:
    are the result of the vascular changes associated with teh inflammatory process including vasodialtion and increased capilary permability. The symptoms include redness, swelling, heat, and pain
  26. Systemic Manifestations of inflammation :
    are fever and increases in levels of circulating leukocyets and plasma proteins
  27. Chronic inflammation:
    • acute inflammation lasting longer than 2 weeks
    • characterized by a dense infiltration of lymphocytes and macrophages. The body may wall off and isolate the infection to protect against tissure damage by fromation of a granuloma
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Patho Chapter 5