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Name the 4 primary stages and their timeline
- Early changes (<24hr)
- Middle changes (1-3 days)
- Later changes (3-7 days)
- Healing (>7 days)
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Name the 3 changes in early infarct histology
- 1. No initial histological changes in myocardium
- 2. Coagulative necrosis (get contraction bands)
- 3. Neutrophil response
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Contraction band/coagulative necrosis (<24hr)
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Name the 3 changes in middle infarct histology
- 1. Neutrophils (~24hr)
- 2. Cellular Debris
- 3. Macrophage infiltration (~3 days)
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1-3 day myocardial infarct with macrophage response
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Name the 3 changes in later infarct histology
- 1. Macrophages (3 days)
- 2. Phagocytosis (4-7 days, greatest risk for myocardial rupture)
- 3. Fibroblast infiltration (7 days)
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Phagocytosis phase of late-stage MI (4-7 days)
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Name the 3 changes in healing infarct histology
- 1. Fibroblast infiltration (7 days)
- 2. Neovascularization
- 3. Collagen/fibrin deposition (weeks, gives myocardial scar)
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Healed myocardial infarct (endocardium with no fat cells)
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What are 6 major post-infarct complications?
- Arrythmia
- Myocardial rupture (wall, septum, papillary)
- Pericarditis (Dressler's/fibrinous)
- Mural thrombus
- Ventricular aneurysm
- Ventricular remodeling
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