Pathophys Test 2

Enterotoxigenic E. coli

Secretes toxins
Enteropathogenic E. coli
- Adheres to mucosal cells
- Destroys microvilli
- Leads to absorption problems
Enteroinvasive E. coli

Invades and injures mucosa
Enterohemorrhagic E. coli (EHEC)
- Adheres to and damages epithelial cells
- Does not invade mucosa
- Serotyped 0157:H7
- Found in intestines of cattle
Most worrisome complication of EHEC
- Bloody diarrhea --> decreased volume --> renal failure
- Hemolytic uremic syndrome (HUS)
HUS - Hemolytic Uremic Syndrome
- Hemolytic anemia
- Thrombocytopenia
- Acute renal failure
Connection between E. coli and HUS
- E. coli in bloodstream releases shiga-like toxins that bind to glomerular capillaries
- Inactivates protein synthesis and ribosomal activity
- Injury to cells
- Platelet aggregation and fibrin replacement in glomerular capillaries --> Acute Renal Failure
- Also causes RBC hemolysis

Author

cgordon05

12101

Card Set

Pathophys Test 2

Description

EColi and HUS

Updated

2010-03-27T02:39:27Z

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