Pathophys Test 2

  1. Enterotoxigenic E. coli
    Secretes toxins
  2. Enteropathogenic E. coli
    • Adheres to mucosal cells
    • Destroys microvilli
    • Leads to absorption problems
  3. Enteroinvasive E. coli
    Invades and injures mucosa
  4. Enterohemorrhagic E. coli (EHEC)
    • Adheres to and damages epithelial cells
    • Does not invade mucosa
    • Serotyped 0157:H7
    • Found in intestines of cattle
  5. Most worrisome complication of EHEC
    • Bloody diarrhea --> decreased volume --> renal failure
    • Hemolytic uremic syndrome (HUS)
  6. HUS - Hemolytic Uremic Syndrome
    • Hemolytic anemia
    • Thrombocytopenia
    • Acute renal failure
  7. Connection between E. coli and HUS
    • E. coli in bloodstream releases shiga-like toxins that bind to glomerular capillaries
    • Inactivates protein synthesis and ribosomal activity
    • Injury to cells
    • Platelet aggregation and fibrin replacement in glomerular capillaries --> Acute Renal Failure
    • Also causes RBC hemolysis
Card Set
Pathophys Test 2
EColi and HUS