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What is extracellular matris?
- ECM is made of collagen which is resistant to crushing or crushing
- This what gives bones their strength
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Four types of tissue
connective, epithelial, nervous, muscular
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Collagen is the major componet of (what)?
Collagen is secreted by what?
Describe the struture of collagen
- Collegan is the major component of the ECM (extracelluar matrix)
- Collegan is secreted by the procollagen
- long, stiff triple stranded helcial structure polypeptide --> secreted outside the cell in procollegan form which then matrix proteases will remodel it and it will orient into the correct manner
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What is fibronetin?
attaches collegan to cells provides important linkage
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What is integrins?
Integrins are transmembrane proteins connect the cytoskeleton to the ECM
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What is the ECM and what are the important components:
- Extracellular matrix secretes cells; made of collagen resisting crushing, gives support and strength
- ECM is made of collagen, fibronetction, laminin fibers, integrins, proteoglycan gel
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What makes up 25% of the total protein mass?
Collagen
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What are proteoglycans and GAGs?
Proteoglycans are extracellular proteins which link to GAGs
GAGs are specific sugar oligosachrides (negative charge)
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Details about GAGs:
- Strong hydrophilic --> attract water --> swell which leads to huge volume compared to their mass
- Gel like protein; repeat dissachrides
- GAGs form large collection with proteins to form proteoglycans
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