-
-
-
Mechanism of Action
Syntheic opioid agonist that acts on opioid receptors to produce analgesia, euphoria, respiratory and physical depression; a schedule II drug with potential for physical dependency and abuse.
-
Indications
Analgesia for moderate to severe pain.
-
Contraindications
Hypersensitivity to narcotic agents, diarrhea caused by poisoning, patients taking MAOI's, during labor or delivery of a premature infant, undiagnosed abdominal pain or head injury.
-
Adverse Reactions
Respiratory depression, sedation, apnea, circulatory depression, arrhythmias, shock, euphoria, delirium, agitation, hallucinations, visual disturbances, coma, seizures, headache, facial flushing, increased ICP, nausea, vomiting.
-
Drug Interactions
Do not give concurrently with MAOI's (even with a dose in the last 14 days!). Exacerbates CNS depression when given with these medications.
-
How Supplied
50/mL in 1-mL prefilled syringes and Tubex.
-
Dosage and Administration
Adult: 50-100 mg IM, SC or 25-50 mg slowly IV.
Pediactric: 1-2 mg/kg/dose IV, IO, IM, SC.
-
Duration of Action
Onset: IM: 10-45 minutes; IV: immediate.
Peak Effect: 30-60 minutes.
Duration: 2-4 hours.
-
Special Considerations
Pregnancy safety: Category C. Use with caution in patients with asthma and COPD. May aggravate seizures in patients with known convulsive disorders. Naloxone should be readily available as antagonist.
|
|