WBC's that are normally seen in the peripheral blood are:
Neutophils, eosinophils, basophils, lymphocytes, and monocytes
Neutophils, eosinophilsm and basophils are included in the general catagory of?
granulocytes
Are also known as polymorphonuclear neutrophilic leukocytes and segmented neutrophilic granulocytes.
Neutrophils
Neutrophils usually constitute __________of the blood's WBCs
40-75%
less mature neutophil in which the nucleus has not yet segmented.
Bands
Bands make up _______ of the WBCs but increase dramatically with severe infection.
0-6%
In various abnormal conditions, the more immature cells may be seen:
metayelocyte, myelocyte, promyelocyte, and myeloblast
Contain enzymes that destroy bacteria and other invaders. They are capable of phagocytosis.
Neutrophils
WBCs come in five different types, the most commonof which is the?
Neutrophil (1st major line of defence)
are produced in the bone marrow where they are stored in lerge numbers.
Neutophils
How long are neutophils in the blood before they pass into the tissues where they perform therir primary function and die soon after.
6-12 hours
The life span of a neutrophil is about ______ from myeloblast in the bone marrow to its death in the tissues.
10 days
The neutrophil spends a shorter time in the bone marrow pool when?
significant infection is present.
Once neutrophils pass into the circulating blood, they are continuopusly and rapidly exchanged between two intravascular pools:
the circulating and marginated pools
Represents neutophils that are freely circulating in the bloodstream.
Circulating pool
represents a large number of neutrophils that are adhering to the walls of the blood vessels.
Marginated pool
Marginated neutrophils are not counted in the?
CBC
Neutrophils shift from one pool to the other based on?
physiological conditions
Physical or emotional stress causes a sudden release of catecholamines that liberates a large number of marginated neutrophils and results in what is called:
pseudoneutrophilia
occurs when a large number of the neutrophils in the circulating pool shirt to the marginated pool.The actual number of neutrophils in the intrvascular pool is not decreased with this.
Pseudoneutropenia
a type of granulocyte with large granules that stain bright red.
Eosinophils
have large granules that strongly take up the basic stain (dark blue to purple)
basophils
These cells appear to hvae complementary interactions in allergic reactions.
Eosinophils and basophils
these also help defend the body against parasitic infestations.
Eosinophils
Eosinophils make up _______ of WBCs
0-6%
Basophils make up _____ of WBCs
0-1
These cells are important in defence agains viral, TB and fungal infections
lymphocytes
two types of lymphocytes
T cells and Bcells
lyphocytes involved with cell mediated immunity
Tcells
lymphocytes that are involved in antibody production
B cells
Lymphocytes make up _______ of WBCs. Most are T cells
20-25%
separation of T cells abd B cells can be done only with special studies. These studies have a spcial anitbody that react with the T or B cell. That antibody is called
monoclonal
T cells ahve two sub groups:
helper and suppressor cells.
AKA inducer cells provide help for anibody production and other immune responses and identified by a unique surface antigen known as CD4.
Helper (T4 cells)
these cells play a role in suppressing or dampening immune responses. Uniques antogen CD8 and called T8 cells.
Suppressor cells
CD4 counts provide infor about PT's w/?
AIDS
the largest WBC, make sup 2-10% of leukocytes and is know as a macrophage
monocytyes
The primary function of the monocyte is?
phagocytosis
In the lung, these play a key role in clearing inhaled particualte matter.
Macrophages
is an abnormal increase in the WBC count
Leukocytosis
An abnormal decrease in the WBC count is known as
leukopenia
an increase in neutrophils is called neutrophilia or a
neutrophilic leukocytosis
a decrease in neutrophils is called
neutopenia
Increase of neutophils as a result of proliferation of cells in the bone marrow.
Primary
Increase of neutrophils as a result of stimulation of the bone marrow secondary to other diseases or disorders,
Secondary.
is common responce to inflamation and infection
neutrophilia
Significant leukocytosis with a left shift (increase in bands) indicates the bone marrow is attempting to respond to
infection
occurs when marginated neutrophils are shifted to the circulating pool and are counted in the CBC
pseudoneutrophilia
aka eosinophilic leukocytosis (increase in eosinophils) is often seen in allergic states and parasitic infestations
Eosinophilia
eosinophilic leukocytosis (increase in eosinophils) is often seen in allergic states and parasitic infestations ______, but it can also be seen in certain skin and gastrointestinal disorders
eosinophils
increase in basophils) is associated with many of the same disorders that cause eosinophilia and myeloproliferative disorders.
basophilia
is a generic term that includes spirometry and flow volume loop (FVL) before and after bronchodilator inhalation, lung volume studies, and diffusion capacity (DL) studies.sometimes also includes airway resistance (Raw), arterial blood gas (ABG) measurements, pulmonary response to exercise, and bronchial provocation.
Pulmonary function testing (PFT)
measures inspiratory and expiratory airflow rates and usable lung volume
spirometry
evaluate both usable and residual lung volumes
Lung Colume Studies
measure lung alveolar surface area available for gas exchange
DL studies
assess the balance between ventilation and lung perfusion
ABG measurements
measures physical responses to exercise.
Pulmonary exercise stress testing (PEST)
measures the airway response to noxious stimuli and is useful in identifying patients with asthma.
Bronchoprovocation testing
is the most important factor influencing lung size and predicted values.
Height
Weight is relatively unimportant in determining lung volumes and flow rates unless they have a BMI of
>30
Males generally have larger lung volumes and flow rates, but who achieves max. lung volume at a younger age?
females
may be relatively accurately calculated by measuring the inside of the chest wall to determine total intra-thoracic volume, then measuring the outside of the heart and great vessels to determine intrathoracic tissue volume
TLC
is the amount of gas left in the lung after the patient exhales all that is physically possible. It is obtained from the studies already described in the TLC section
Residual volume (RV)
can be determined by subtracting the SVC from the TLC or by subtracting the ERV from the FRC (described later). It is usually increased when air trapping is present.
RV
is the volume that can be maximally exhaled from a resting lung status. It can be easily measured with a spirometer. Obesity, poor effort, and restrictive lungs reduce it.
expiratory reserve volume (ERV)
is the amount of gas left in the chest when the patient is at resting lung status. It is obtained with the studies already described in the TLC section. It represents a balance between the expanding chest wall forces and the contractile rebound forces of elastic lung tissue.
Functional residual capacity (FRC)
an age-related, progressive, bilateral hearing loss, is the most common cause of auditory impairment in the United States. This condition affects about 23% of adults between the ages of 65 and 75 years. In the 70- to 80-year-old age group, as many as 50% of older adults have hearing impairment that actually affects their communication skills
Presbycusis
defined as a symptom rather than a disease, is also more prevalent in the elderly.is an auditory perception not caused by external sounds. It may be described as ringing, buzzing, roaring or chirping.
Tinnitus
is defined as a damaging effect on the eighth cranial nerve or in the organs of hearing or balance. The diminished hearing capacity that health care practitioners observe in institutionalized patients may be inflated
Ototoxicity
Simple and accurate methods assess the presence or absence of hearing loss. Some that are commonly used are :
whispered voice, a tuning fork, finger rub, a portable AudioScope, and the Hearing Handicapped Inventory for the Elderly-Screening (HHIE-S) questionnaire.
a normal age-related change in the lens of the eye, usually results in correctable farsightedness. can occur in adults as early as age 40, it is much more common in older adults
Presbyopia
has been identified as the second most prevalent disability in adults over age 65 years
Visual impairment
Low pH of plasma. An abnormal buil-up of hydrogen ions in the blood.
Acidemia
A pH less than normal.
Acidosis
High pH of plasma. An abnormal decrease in they hydrogen ion concentration of the blood.
Alkalemia
A pH elevated above normal.
Alkalosis
Occurs when the portion of the tidal volume (VT) that does not come into contact with blood flow is increased.
Dead Space Ventilation
Abnormal elevation of PaCO2.
Hypercapnia
Abnormal elevation of arterial CO2 levels.
Hypercarbnia
Abnormal decrease of PaCO2.
Hypocapnia
Abnormal decrease of arterial CO2 levels.
Hypocarbnia
An abnormal reduction in the partial pressure of O2 in the arterial blood.
Hypoxemia
A lack of oxygen.
Hypoxia
The maximum amount of air the patient exhales after a fall, deep inspiration.
Forced Vital Capacity
Adding two or more of the lung volumes together results in _________.
Lung Capacity
Are clinically useful measurements of lung function such as VT, IRV, or ERV.
Lung Volumes
The vlume of air inhaled or exhaled in 1 min.
Minute Volume (VE)
A piece of equipment that measures a patient's airflows and volumes of gas moved over time.
Spirometer
Apiece of equipment that measures a patient's airflows and volumes of gas moved over time and is capable of displaying the information in graphic form.
Spirograph
The tracing produced by a spirograph.
Spirogram
These studies provide vital Info. about the patient's cardiopulmonary status. They measure the ability of the lungs to put O2 into, and remove CO2 from, the blood.
Arterial blood gas
In the ABG test this is also analyzed. is often important to evaluate in the patient w/ cardiopulmonary disease.
Acid-Base status
What is the common site where and ABG is drawn?
radial artery
How do you transport and ABG?
in an ice bath
What must be removed from the blood sample before it is sent for analysis?
air bubbles
How long should you compress the site from and ABG draw?
5-10mins
means the partial pressure of O2 in the arterial blood.
PaO2
reflects the ability of the lungs to allow the transfer of O2 from the enviroment to the circulating blood.
PaO2
will be affected with diffusion defect and by overall hypoventilation and may lead to hypoxemia
PaO2
is a PaO2 below the predicted or normal range
Hypoxemia
Means SaO2
Oxygen saturation
is an index of the actual amount of O2 bound to hemoglobin expressed as a percentage of the total capacity and can be determined only from a co-oximeter.
SaO2
What is CaO2
Arterial oxygen content
is a function of the amount of oxygen bound to hemoglobin and dissolved in the plasma.
CaO2
O2 assesment involves two basic steps.
The measurement provided by ABGs and the patient's tissue oxygenation status.
O2 in the blood i primarily bound to?
Hb
A smaller portion of O2 compaired to the Hb is carried by?
Blood plasma
SaO2 represents what?
the amount of O2 bound to Hb
Is the measurement of the pressure or tention of oxygen in the plasma of the arterial blood,
PaO2
PaO2 reflects the ability of the lungs to allow the transfer of O2 from the enviroment to _______?
the circulatting blood
Normal PaO2 is based on three things, what are they?
Barometric pressure, Age, and FiO2
As age increases the efficientcy of the lungs to oxygenate the blood is ___?
reduced
The Formula for PaO2.
FiO2(PB-PH2O)-(PaCO2X1.25)
One of the causes of hypoxemia, occurs in most patientswhen th inhaled gas does not match up with pulmonary cpillary blood flow.
V/Q mismatch
Means ventilation/perfusion mismatch
V/Q mismatch
A cause of hypoxemia, pulmonary capillary blood, which flows by alveoli that are not ventilated, does not pick up and O2 and thus returns to the systemic circulation unchanged.
Shunt
Causes hypoxemia, is abnormalities in the lung structure that slow the diffusion of O2 from the inhaled gas through the alveolar-capillary membrane.
diffusion defect
Hypoxemia caused by low breathing
pure hypoventilation
A patient with lung disease will usually have hypoxemia due to both ______ and ______.
V/Q mismatch and hypoventilation
hypoxemia can be cause by breathing in____ or from a faulty machine?
low PiO2
Normal value of SaO2
>95%
is an index of actual amount of O2 bound to Hb and is expressed as a percentage of the total capacity.
SaO2
True reliable SaO2 can only be calculated by a?
Co-Oximeter
PaO2 and SaO2 have a non-linear relationship. True or false?
T
Normal value of HbCO.
~.5%
is a reflection of quantity of CO bound to the Hb molecules and can be obtained only from the co-oximeter
HbCO
is a highly diffusable, odorless, and colorless gas that has an inffiinty for Hb 200 to 250 times that of O2.
CO
Inhalation of gas containing CO will result in shifts of the oxyhemoglobin curve dissociation curve. It will curve to the ____?
left
Presence of CO does what to the CaCO2?
it decreases
CO promoted Tissue
hypoxia
It reduces the O2 carrying capacity of the Hb and inhibits unloading of O2 at the tissue.
CO
Occurs when the respiratory system fails to oxygenate arterial blood adequately.
Hypoxemia
Large P(A-a)O2 indicates?
severe respiratory abnormality.
Hypoxemia occuring with a normal P(A-a)O2 may be the result of?
low PiO2
if the sum of PaO2 and PaCo2 is 110 - 130 mmHg then the cause of hypoxemia is?
Low PiO2
if the sum of PaO2 and PaCO2 is less than 110 mmHg then the cause of hypoxemia is?
defects in the lung's ability to oxygenate the blood.
if the sum of PaO2 and PaCO2 is greater than 130 mmHg than the cause of hypoxemia is?
is on supplimental breathing or an error.
Assessment if the Hb concentration from either the complete blood cell count or co-oximetry measuremtn is crucial for identiofying the potential for?
CaC02
A reduction of CaO2 can occur with?
CO poisoning
is identified when trhe O2 level drops below 90%
Cyanosis
Cyanosis is not recognized in patients with ____.
Anemia
remove a small amount of acid but help restore the buffer capacity of the body fluids by adding HCO3.
The Kidneys
Resp. and renal disfunction may cause.
acid-base disorders
is an abnormal condition in which there is a primary reduction in alveolar ventilation relative to the rate of CO2 production. It indicates that ventilation is inadequate.
Respiratory acidosis
in acute respiratory acidosis Plasma HCO3 increases ____ for every 10-15mmHg that PaCO2 increases.
1mEq/L
In chronic respiratory acidosis plasma HCO3 increases ____ for every 10-15 mmHG that PaCO2 increases.
4 mEq/L
is an abnormal condition in which there is a primary increase in alveolar ventilation relative to the rate of CO2 production.
Respiratory Alkalosis
Acute Resp. Alkal. will result in a decrease of HCO3 of ____ for every 5mmHg of PaCO2 decreases.
1mEq/L
Chronic resp. alkal. will result in a decrease of HCO3 of _____ for every 10mmHG of PaCO2 decreases.
5mEq/L
is a generic term that includes spirometry, flow volume loop, before and after bronchodialtor inhalation, lung volume studies, and diffusion capacity testing.