-
Giant Cell Vasculitis
- Most common in older adults
- Large to medium vessels (temporal, ophthalmic, aorta)
- Nodular intimal thickening
- Granulomatous infiltrate
- Skip lesions
- Fever, pain, vision changes, HA
- Treat with steroids
-
Takayasu Arteritis
- Granulomatous
- Aorta and main branches
- Pts <50
- Pulseless disease when transmural fibrosis
-
Polyarteritis nodosa (PAN)
- Small to medium muscular arteries
- Immune complex mediated (30% hep B, no ANCA)
- Young adults
- Segmental transmural necrotizing (fibrinoid) inflammation. Neutrophilic infiltrate
-
Kawasaki syndrome
- Mucocutaneous lymph node syndrome
- Erythema and edema in hands and feet. Enlarged lymph nodes.
- All arteries, mostly medium. Often coronary.
- Pts <4y
-
Microscopic Polyangiitis
- Leukocytoclastic vasculitis
- Breakdown of neutrophils
- Small vessels
- Kidneys and lungs and more
- pANCA often, no immune complex deposition
- Fibrinoid necrosis of media
-
Churg-Strauss Syndrome
- Allergic granulomatosis and angiitis
- Small vessels
- Lungs
- Increased eosinophils
- Fibronoid necrosis, extravascular granulomas in lung
- pANCA
-
Wegener Granulomatosis
- 1. Acute necrotizing granulomas of respiratory tract
- 2. Necrotizing or granulomatus vascultiis of sm/med vessels
- 3. Renal disease
- cANCA
- men>women
-
Thromboangitis Obliterans
- Buerger
- sm/med vessels
- Pt = Smokers <35y
- Nodular phlebitis, cold sensitivity
-
Glomus tumor
- distal digits
- modified sm m cells
- benign, painful lesion
-
Bacillary angiomatosis
- immunocompromised peeps (AIDS)
- Bartonella
-
Kaposi sarcoma
- 1. chronic, old easter europeans
- 2. lymphadenopathic, african kids
- 3. transplant immunosuppression
- 4. AIDS associated
-
pANCA
- Microscopic polyangiitis (leukocytoclastic vasculitis)
- Churg-Strauss syndrome
|
|
