1. Trade Name
  2. Class
    Benzodiazepine; sedative; anticonvulsant
  3. Mechanism of Action
    Anxiolytic, anticonvulsant, and sedative effects; suppresses propagation of seizure activity production by foci in cortex, thalamus, and limbic areas.
  4. Indications
    Initial control of status epilepticus of severe recurrent seizures, severe anxiety, sedation.
  5. contraindications
    Acute narrow-angle glaucoma. Coma, shock, or suspected drug abuse.
  6. Adverse reactions
    Respiratory depression, apnea, drowsiness, sedation, ataxia, psychomotor impairment, confusion, restlessness, delirium, hypotension, bradycardia
  7. Drug interactions
    May precipitate CNS depression if Pt. is already taking CNS depressant medications.
  8. How supplied
    2 and 4 mg/mL concentrations in 1mL vials
  9. Dosage and Administration
    Note: when given IV or IO, must dilute with equal volume of sterile water or sterile saline; when given IM, lorazepam is not to be diluted.

    Adult: 2-4 mg slow IV at 2 mg/min of IM; may repeat in 15-20 minutes to maximum dose of 8 mg. For sedation: 0.05 mg/kg up to 4 mg IM

    Pediatric: 0.05-0.20 mg/kg slow IV, IO slowly over 2 minutes or IM; may repeat in 15-20 minutes to maximum dose of 0.2 mg/kg
  10. Duration of Action
    • Onset: 1-5 minutes
    • Peak: variable
    • duration: 6-8 hours
  11. Special considerations
    Pregnancy saftey: Catergory D. Monitor BP and respiratory rate during administration. Have advanced airway equipment readily available. Inadvertent arterial injection may result in vasospasm and gangrene. Lorazepam expires in 6 weeks if not refrigerated.
Card Set
paramedic pharmacology