Antimuscarinics, Atropine etc.

Atropine major pharmacological effects (6)
- Increased HR
- Decreased secretion of exocrine glands
- Smooth muscle relaxation
- Mydriasis
- Cycloplegia (prevents distant vision)
- Dose-related CNS effects
Atropine blocks ?

All muscarinic receptors, but dependent on dose
Atropine pharmacokinetics
- Rapid oral absorbtion
- Tertiary amine - penetrates BBB
Atropine adverse effects (9)
- Xerostomia (block M3) dry mouth/eyes
- Anhidrosis (block M3), hyperthermia, heat stroke
- Urinary retention
- Constipation
- Makes GERD worse
- Tachycardia (block M2)
- Bradycardia
- Blurred vision
Atropine drug interactions (3)
- Additive effects
- Antihistamines
- May alter absorbtion of other drugs
Tolterodine use

Overactive bladder
Dicyclomine uses

Relieve muscle spasms of GI tract
Oxybutynin use (1)

Overactive bladder
Benztropin use (1)

Alzheimer's
Glycopyrrolate uses (4)
- Reduces salivary glands
- Vagal-induced bradycardia during anesthesia
- Adjunct for PUD
- Reverse n euromuscular blockade during anesthesia
- Abnormal drooling in kids with cerepral palsy
Tiotropium use (1)

Bronchospasm associated with COPD

Author

jaguavai

120082

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Antimuscarinics, Atropine etc.

Description

Antimuscarinics, Atropine

Updated

2011-12-01T18:26:36Z

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