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Anticholinergic Drugs
Ipratropium bromide (Atrovent nasal spray)
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Indication
- Second or third line treatment for allergic rhinitis.
- Useful for vasomotor rhinitis.
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MoA
- Blocks the action of acetylcholine at parasympathetic sites in the mucosa
- Competes with acetylcholine for M3 receptor sites(anticholinergic, major), and binds nonselectively to M2 receptor sites(cholinergic, minor)
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Onset of action
Rapid, several minutes
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SEs
- Severe nasal drying
- Epistaxis
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Contra
Hypersensitivity to the drug
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Drug Interactions
Anticholinergics increase the effects.
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