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Respiratory Pharm

  1. Albuterol
    MOA
    • activation of adenylyl cyclase -> cAMP
    • - decrease intercellular Ca2+
    • - inhibition of MLC kinase activation
    • - MLC phosphatase activation
    • - Ca2+ dependent K channels opened
    • ULTIMATE EFFECT: relax airway smooth muscle
  2. Salmeterol
    • activation of adenylyl cyclase -> cAMP
    • - decrease intercellular Ca2+
    • - inhibition of MLC kinase activation
    • - MLC phosphatase activation
    • - Ca2+ dependent K channels opened
    • ULTIMATE EFFECT: relax airway smooth muscle
  3. Aminophylline
    EFFECT
    • Bronchodilation
    • dec eosinophils & neutrophils
    • inhibit late repsonse
  4. Theophylline
    EFFECT
    • Bronchodilation
    • dec eosinophils & neutrophils
    • inhibit late repsonse
  5. Ipratropium
    MOA
    • competitive inhibitor @ muscarinic receptors (M2)
    • block smooth airway contraction
    • blocks inc in mucus secretion
  6. Tiotropium
    MOA
    • competitive inhibitor @ muscarinic receptors (M2)
    • block smooth airway contraction
    • blocks inc in mucus secretion
  7. Corticosteroids
    MOA
    • inhibit airway infiltration
    • inc anti-inflammatory genes
    • dec PG and Leukotriene synthesis
    • B2 agonist potentiator
  8. Use in urgent asthma attack
    prednisolone, prednisone, hydrocortisone
  9. Beclomehtasone
    MOA
    • inhibit airway infiltration
    • inc anti-inflammatory genes
    • dec PG and Leukotriene synthesis
    • B2 agonist potentiator
  10. Budesonide
    MOA
    • inhibit airway infiltration
    • inc anti-inflammatory genes
    • dec PG and Leukotriene synthesis
    • B2 agonist potentiator
  11. ciclesonide
    MOA
    • inhibit airway infiltration
    • inc anti-inflammatory genes
    • dec PG and Leukotriene synthesis
    • B2 agonist potentiator
  12. Flunisolide
    MOA
    • inhibit airway infiltration
    • inc anti-inflammatory genes
    • dec PG and Leukotriene synthesis
    • B2 agonist potentiator
  13. Fluticasone
    MOA
    • inhibit airway infiltration
    • inc anti-inflammatory genes
    • dec PG and Leukotriene synthesis
    • B2 agonist potentiator
  14. mometasone
    MOA
    • inhibit airway infiltration
    • inc anti-inflammatory genes
    • dec PG and Leukotriene synthesis
    • B2 agonist potentiator
  15. triamcinolone
    MOA
    • inhibit airway infiltration
    • inc anti-inflammatory genes
    • dec PG and Leukotriene synthesis
    • B2 agonist potentiator
Author
lazzsant
ID
119234
Card Set
Respiratory Pharm
Description
Beevers respiratory pharm
Updated

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