Lab Final

 How do you find the sensitivity requirement? Put 6mg on one side of the balance and measure the deviation, then put 10g on both sides and add 6mg on one side and measure the deviation and compart to the deviation PLot the weight against the number of scale divisions shifted by each weight on graph paperMake a straight line and measure the weight that will cause a shift of one scale division What is the equation for percent error? Percent error = [(sensitivity requirement)(100)]/[quatity desired] What is the equation for the smallest quantity to be weight? Smallest quantity to be weight = [(Sensitivity requirment)(100)]/[Permissible percent of error] What is the aliquot method? Weigh a multiple of the quantitydesiredDilute the multiple in a suitable mannerWeigh or measure an aliquot of the final mixture What is geometric dilution? When mixing a small amount of drug (mg level) with a large amount of a second. the drug is placed in the mortar with equal bulk of the other ingrediant. The two ingredients are triturated until intimately mixed . Then equal bulk of the second ingredients is added to the mixture and the powders are intimately mixed Define: capsule Are solid dosage forms in which the drug substances is enclosed in either a hard or solf , soluble container of shell of a suitable form of gelatin What is the punch method? Manually filling capsules one by oneFlatten the powder so that it is no greater than 1/3 the length of the capsule What is the most common solid dosage form? Tablet Define: tablet Unit form of solid drugs prepared by compaction Define: stick topical medicated dosage form for adminsitrating topical medicationsChapstick What are the two methods for preparing onintments? FusionIncorporation WHat is the incorporation method? The components of the ointments are mixed together by various means until a uniform preparation has been atained Define: ointment Are semi-solid preparations containing dissolved or dispersed drugs or no drugs intended for external application to the body Define: cream are emulsified ointmentsViscous liquid or semisolid emulsions systems either oil in water or the water in oil "creamy white" appearance What method is generally used to make creams? Fusion(THe oil and aqueous phases are heated separately, the emulsifier agent is added to the aqueous phase and the emulsion is formed by slow addition of the oil phase) Define: lotion are usually liquid suspensions of emulsions intended for external application to the skin and mucosa Define: pastes basucally ointments into which a higher percent of insoluble solids have been added, as much as 50% by weight in some instances cream: cetyl ester wax stiffening agent cold cream: mineral oil oleagenous vehicle cold cream: water aqueous vehicle cream: sodium borate emulsifing agent paste: starch stiffening agent lotion: zinc oxide, calamine active ingredients with protectant and astringent properties lotion: glycerin levigating agent lotion: microcrytalline cellulose suspending agent lotion: carboxymethylcellulose suspending agent lotion; calcium hydroxide solution aka lime watervehicle with antringent property Define: gel are semisolid systems consisting of suspnsions made up of either small inorganic particles or large organic molecules interpenetrated by a liquidare semigrid systems in which the movement of the dispensing medium is restricted by an interlacing three dimensional network What gelling agent is primarly used in aqueous systems carbomer gel: hydroxypropylcellulose gelling agent gel: propylene glycol levigating agent gel: polysorbate 80 tween 80solubilizing agent gel: 70% isopropyl alcohol solvent, vehicle gel: carbomer 934 gelling agent gel: alcohol solvent gel: p water solvent define: suppositories are solid dosage forms intended for insertion into body orifices where they melt, soften, or dissolve and exert localized or systemic effects What are the three classes of suppository bases? fatty/oleagenouswater miscible basesmiscellaneous, combination of lipophilic and hydrophilic bases What are fatty/oleagenous bases? cocoa butterhydrogenated fatty acids of vetgetable oilskernal oilfatty acid glyceride such are glyceryl monopalmitate What suppository base melts body temperature to release the medicament fatty/oleagenous bases what is an example of water-miscible base? polyethylene glycol What type of suppository base dissolve in the body cavity? water miscible What are the two methods of making suppositories? molding from a meltcold compression suppository: PEG water miscible bases define: solutions as liquid preparations that contain one or more soluble chemical substances usually dissolved in water or water miscible pharmaceutical solvents and that do not, by reasons of their ingredients, method of preparation or used, fall into other groups of product define: elixirs aqueous pharmaceuticl solutions sweetened hydroalcoholic define: syrups aqueous pharmaceutical solutions containing sugar What is a simple solution? composed of one substances what is compound solution? solution containing more than on esolute What is a chemical solution? solutions whose components are the product of a chemical reaction What is a saturated solution? Solutions containing all the solute that the solvent will hold define: solvent compose the major portion of a solution Drugs adminstered as __________ liquids are generally absorbed much more rapidly aqueous liquids solution: polysorbate 20 levigating agent solution: ethanol 95% co-solvent solution: sodium saccharin sweetner solution: sodium benzoate antimicrobial solution: sorbitol 70% solution sweetner solution: tween 80 solubilizing agent solution: sodium saccharine sweetener solution: lemon oil flavor agent solution: citric acid acidifier/stabilizer solution: glycerin thickening solution: methylparaben preservative What are the components of an syrup? sugarantimicrobial preservativeflavorantscolorants What is the concentration of sugar in simple syrupe NF 85% define: elixir are clear sweetened hydroalcoholic solutions intended and are usually flavored to enhance pala What percent of alcohol is needed to make it self preserved? 10 to 12 percent elixir: cocoa flavor elixir: sucrose sweetner elixir: glycerin levigating agent elixir: sodium chloride stabilizer elixir: vanillin flavor elixir: sodium benzoate antimicrobial syrup: benzoic acid antimicrobial preservative syrup: disodium calcium EDTA chelating agent, stabilizer syrup: propylene glycol thickening agent, co-solvent, sweetner syrup: alcohol co-solventantimicrobial syrup: saccharin sweetner define: suspension are preparations containing finely divided drug particles (suspensoid) distributed somewhat uniformly throughout a vehicle (dispersion medium) what are the problems presented to a suspension? aggregationsedimentationimpaction suspension: glycerylmonostearate suspending agent suspension: glycerin levigating suspension: sodium lauryl sulfate surfactant suspension: methylparaben preservative suspension: propylparaben preservative define: emulsions is a dispersion in which the dispersed phase (internal phase) is composed of smal globules of a liquid distributed throughout a vehicle/medium (external phase) in which it is imiscible emulsion: cottonseed oil oleagenous phase solvent emulsion: polyoxyethylene sorbitan-monostearate (tween 60) emulsifier agent emulsion: sorbitan monooleate emulsifier agent emulsion: sodium saccharin sweetener emulsion: methylparaben preservative emulsion: sodium benzoate preservative Authorba ID119083 Card SetLab Final DescriptionLab final Updated2011-11-28T03:47:54Z Show Answers