1. Trade Name
  2. Class
    Benzodiazepine, sedative-hypnotic, anticonvulsant
  3. Mechanism of action
    Potentiates effects of inhibitory neurotransmitters. Raises seizure threshold. Induces amnesia and sedation.
  4. Indications
    Acute anxiety states, acute alcohol withdrawal (delirium tremens), muscle relaxant, seizure activity, agitation. Analgesia for medical procedures (fracture reduction, cardioversion)
  5. Contraindications
    Hypersensitivity, glaucoma, coma, shock, substance abuse, head injury
  6. Adverse reactions
    Rrepiratory depression, hypotension, drowsiness, ataxia, reflex tachycardia, nausea, confusion, thrombosis, and phlebitis
  7. Drug interactions
    Incompatible with most drugs, fluids
  8. How supplied
    10mg/5-mL prefilled syringes, ampules, vials, and tubex.
  9. Dosage and Administration
    • Seizure activity: adult: 5-10 mg IV every 10-15 minutes prn (5 mg over 5 min)(maximum dose, 30mg)
    • Seizure activity: Pediatric: 0.2-0.5mg slowly every 2-5 minutes up to 5mg (maximum dose, 10mg/kg).
    • Rectal diazepam: 0.5mg/kg via 2" rectal catheter and flush with 2-3 mL air after administration.
    • Sedation for cardioversion: 5-15 mg IV over 5-10 minutes prior to cardioversion.
  10. Duration of action
    • Onset:1-5 minutes
    • Peak effect: minutes
    • Duration: 20-50 minutes
  11. Special considerations
    Pregnancy safety: Category D. Short duration of anticonvulsant effect. reduce dose 50% in elderly Pt.
Card Set
Paramedic Pharmacology