Insulins

Rapid acting insulins (3)
- Aspart (Novolog)
- Lispro (Humalog)
- Glulisine (Apidra)
- - note they all sound like amino acids
Short acting insulin (1)

Recombinant Human ("Regular" or Humulin R)
Intermediate acting Insulin (1)

NPH (Humulin N, Novolin N)
Slow acting insulin
- Detemir (Levemir)
- Glargine (Lantus)
Aspart, Lispro, Glulisine Med Chem

Mutation of 1-2 amino acids to inhibit aggregation of Insulin
Glargine Med Chem

Glargine is soluble at pH 4, but precipitates at physiological pH. This causes slow release.
NPH Med Chem

Complexation of insulin with Protamine reduces insulin's rate of absorbtion
Detemir Med Chem

Attaching a fatty acid slows insulin absorbtion because the fatty acid causes the insulin molecules to aggregate with themselves and albumin
Insulin ADR's (5)
- Hypoglycemia
- Weight gain
- Lipoatrophy at injection site
- Lipohypertrophy at injection site
- Allergy/sensitivity (rare)

Author

jaguavai

117505

Card Set

Insulins

Description

Insulin types and rates

Updated

2011-11-17T16:22:49Z

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