pharm cards

  1. Beta-lactams
    • Penicillin G, Oxacilllin, Ampicillin, Icarcillin, Pipercillin
    • works against gram positive bacteria
    • mech: inhibits steps in cell wall syn & murcin assembly
  2. Penicillian
    • gram postive
    • strep, C. diptheria, syphilis (spirochete)
  3. Ampicillin; Amoxycillian
    • gram negative bactera- Enterococcus, E. coli, H. flu, UTI
    • inhibits cell wall (peptiodogylcan) syn and murcin assembly
  4. Piperacillin/ Tazobactam
    • Big gun for:
    • -nosocomial gram positive & negative & anaerobes in intra-abdominal inections, pnuemonia, or sepsis
  5. Streptomycin;

    • Binds 30s subunit:
    • - Incorporates aberrant prots
    • into cell wall
    • - Blocks initiation at fMET

    TB and Plaque. Rarely used bc of resistance

    toxicity- fluid in ear, leads to vertigo, then ataxia and eventually loss of higherpitched sounds
  6. Gentamincin
    • Aminoglycoside
    • serious gram negative bacteria, nosocomial
    • inhibit protein syn by inhibiting translation. binds 30 s subunit
  7. Vancomycin
    • gram positive bacteria, esp Staph aures- MRSA
    • inhibits peptidooglycan syn & assembly
    • toxicity- flushing! nephro- & ototoxicity, thrombophelbitis
  8. Clindamycin
    gram postive and anaerobes. good for above the diaphragm infections. for lung abcesses & infections w. anaerobes

    binds 50s subunit, inhibits translation

    can cause superinfection w/ c. difficle
  9. Azythromycin, Erythromycin, Clarithromycin
    • Macrolides
    • gram positive bacteria, gram negative bacteria
    • use for URI (comm acquired) and pneumonias: Neisseria, Legionella, Mycoplasma
    • bingds 50s subunit, inhibits translocation
  10. Imipenem, Meropenem
    blocks cell wall syn

    • Big gun for:
    • - Serious nosocomial infection
    • - Broad spectrum = gram (+)
    • and (-) inclding pseudomonas
    • -Drug of choice for enterobacter

    • Must be admin w/Cilistatin b/c Imipenem is inactivated
    • by dihydropeptidases in children
  11. Ceftriaxone
    3rd gen cephalosporin

    • used for gram negative, penicillin-resistant:
    • -N. gonorrhea
    • -N. meningitis
    • - & for pneumonia
  12. Ceftazidine
    3rd gen cephalopsorin

    gram-negative, esp Pseudomonas
  13. Cefeprime
    4th gen cephalosporin

    • big gun for:
    • - MDR organisms
    • -B-lactamase resistant
    • - gram neg nosocomial infections
  14. Ciproflaxcin
    • 2nd gen quinolones
    • inhibits DNA gyrase
    • gram negative esp gasteroenteritis- salmonella, shigella, pseduonomnas
  15. Levoflaxcin
    • 3rd gen quinolones
    • gram positive
    • for:
    • -serious, comm acquired pneomnia
    • -flu, sinisitis, chronic bronchitis
  16. Doxycycline
    binds 30s subunit

    • used for zoonotic infections:
    • -Rocky Mt Spotted Fever (Rickettsia), Lyme disease (Borrelia),
    • -Urerithis (Chlamydia trachomoatis)

    toxicity: turns teeth yellow (binds Ca2+)
  17. Linezolid
    binds 50 s subunit

    VRE resistance gram positive that cause endocartitis, osteomyelitits, bacteremia

    can cause reversible bone marrow suppression
  18. Daptomycin
    disrupts plasma membrane w/o entering cytoplasm

    • MDR gram positive:
    • VRE and Staph
    • For complicated skin and soft tissue infections
  19. Telethromycin
    binds 2 sites on ribosome & therefore hard to develop resistance

    use for: macrolide-resistance strep pneumonaie

    inhibits P450
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