pharm cards

• Penicillin G, Oxacilllin, Ampicillin, Icarcillin, Pipercillin
• works against gram positive bacteria
• mech: inhibits steps in cell wall syn & murcin assembly

• gram postive
• strep, C. diptheria, syphilis (spirochete)

• gram negative bactera- Enterococcus, E. coli, H. flu, UTI
• inhibits cell wall (peptiodogylcan) syn and murcin assembly

• Big gun for:
• -nosocomial gram positive & negative & anaerobes in intra-abdominal inections, pnuemonia, or sepsis

Aminoglyoside

• Binds 30s subunit:
• - Incorporates aberrant prots
• into cell wall
• - Blocks initiation at fMET

TB and Plaque. Rarely used bc of resistance

toxicity- fluid in ear, leads to vertigo, then ataxia and eventually loss of higherpitched sounds

• Aminoglycoside
• serious gram negative bacteria, nosocomial
• inhibit protein syn by inhibiting translation. binds 30 s subunit

• gram positive bacteria, esp Staph aures- MRSA
• inhibits peptidooglycan syn & assembly
• toxicity- flushing! nephro- & ototoxicity, thrombophelbitis

gram postive and anaerobes. good for above the diaphragm infections. for lung abcesses & infections w. anaerobes

binds 50s subunit, inhibits translation

can cause superinfection w/ c. difficle

• Macrolides
• gram positive bacteria, gram negative bacteria
• use for URI (comm acquired) and pneumonias: Neisseria, Legionella, Mycoplasma
• bingds 50s subunit, inhibits translocation

blocks cell wall syn

• Big gun for:
• - Serious nosocomial infection
• - Broad spectrum = gram (+)
• and (-) inclding pseudomonas
• -Drug of choice for enterobacter

• Must be admin w/Cilistatin b/c Imipenem is inactivated
• by dihydropeptidases in children

3rd gen cephalosporin

• used for gram negative, penicillin-resistant:
• -N. gonorrhea
• -N. meningitis
• - & for pneumonia

3rd gen cephalopsorin

gram-negative, esp Pseudomonas

4th gen cephalosporin

• big gun for:
• - MDR organisms
• -B-lactamase resistant
• - gram neg nosocomial infections

• 2nd gen quinolones
• inhibits DNA gyrase
• gram negative esp gasteroenteritis- salmonella, shigella, pseduonomnas

• 3rd gen quinolones
• gram positive
• for:
• -serious, comm acquired pneomnia
• -flu, sinisitis, chronic bronchitis

binds 30s subunit

• used for zoonotic infections:
• -Rocky Mt Spotted Fever (Rickettsia), Lyme disease (Borrelia),
• -Urerithis (Chlamydia trachomoatis)

toxicity: turns teeth yellow (binds Ca2+)

binds 50 s subunit

VRE resistance gram positive that cause endocartitis, osteomyelitits, bacteremia

can cause reversible bone marrow suppression

disrupts plasma membrane w/o entering cytoplasm

• MDR gram positive:
• VRE and Staph
• For complicated skin and soft tissue infections

binds 2 sites on ribosome & therefore hard to develop resistance

use for: macrolide-resistance strep pneumonaie

inhibits P450