-
Short acting Beta 2 agonist for emergency management of asthma?
Albuterol
-
3 Short acting Beta 2 agonists used for asthma?
- Albuterol
- Metaproterenol
- Terbutaline
-
Long Acting beta 2 agonist for asthma?>
Salmeterol
-
Beta 1 and beta 2 agonist?
Isoproterenol
-
Phenylephrine?
alpha 1 agonist--constriciton of bv,-->increase TPR-->increase BP
-
alpha 1, beta 1, beta 2 agonist?
epinephrine
-
Low doses of epinephrine are selective for?
beta1
-
Norepinephrine is selective for what receptors?
alpha 1 and alpha 2
-
Metaprolol is what?
Metaproterenol is what?
-
What is the second messenger for a beta 2 agonist?
camp via adenylyl cyclase which leads to relaxation of smooth muscle
-
Rx for Bronchospasm?
Prophylaxis
-
Contraindications with beta 2 agonist for asthma Rx?
arrythmias
-
Adverse rxns caused by use of beta agonists for astham?
- palpitation
- headache
- hypertension
- anxiety
- tremors
-
IV drug used for acute attack of asthma?
Theophylline
-
MOA of Theophylline?
inhibits phosphodiesterase-->high cAMP-->relaxation of smooth muscle
-
WHy is theophylline not used widely?
it has low TI
-
Drugs that cause theophylline toxicity?
drugs that decrease theophylline toxicity?
- macrolides
- quinolones--ciprofloxacin
- and drugs that inhibit cyt p450
- drugs that induce cyt p450 i.e
- quininde
- phenobarbital
- rifampin
- quinidine
- barbituates
- st. johns wart
- phenytoin
- griseofulvin
- chronic etoh
-
Theophylline is very sensitive to what enzyme activity?
cyt p450
-
Anticholinergic bronchodilator?
atropine
-
S/E of ipratropium?
- mydriasis
- anhydrosis
- dry mouth
- tachycadia
- constipation
- urinary retention
-
DOC for bronchospasm caused by beta blocker?
Ipratropium--anticholinergic
-
What is the adjunct to albuterol in acute asthma in copd?
ipratropium
-
Inhaled corticosteroids for astham?
- Triamcinolone
- Flutacisone
- Beclamethasone
-
Oral corticosteroid for asthma?
prednisolone
-
MOA of corticosteroids in asthma?
- 1. inhibit inflammatory molceules--kinin , histamine
- 2 inhibit Leukotrienes--inhibit vaso and bronchoconstriction
-
Indications for corticosteroids in respiratory conditons?
- bronchial asthma
- bronchial asthma
- chronic bronchitis
-
Adverse rnxs of corticosteroids for asthma?
- Gi distress
- Anorexia
- fungal infections
-
2 LTD4 antagonists used for asthma?
-
Lipooxygenase inhibitor>?
Zileuton
-
Drug used for prophylaxis and chronic treatment of asthma?
Allergic rhinitis
-
Which of the corticosteroidal drugs causes high LFTs?
Zileuton
-
adverse rxns of Montelukast,Zafirluekast?
-
-
MOA of mast cell stabilizers?
inhibit release of histamine, Leukotrienes
-
DOC for red eye associated with conjunctivits?
-
Prophylactic for use in exercise induced asthma attack?
-
S/E of Cromolyn
Nedocromil?
-
Monoclonal antibody for asthma which binds to IgE on mast cells?
Omalizumab
-
S/E of Omalizumab?
increased respiratory tract infections
-
Management of acute asthma in young and old?
beta 2 agonist--Albuterol
-
Rx for asthma which occurs <2days/week or <2 nights/month?
nothing
-
Rx for asthma occuring >2days/week or >2nights/month?
- Low dose inhaled beclamethasone
- or
- Montelukast
- or
- Cromolyn
-
Rx of asthma which occurs daily or >1night a week?
- low dose to medium dose beclamethasone
- +
- salmeterol/montelukast
-
Rx of asthma which occurs daily and frequently at night?
- high dose beclamethasone
- +salmeterol/montelukast
- + oral prednisone
-
Rx of status asthmaticus?
- oxygen
- albuterol
- IV methyl prednisone
- nebuliazed ipratropium
- if still not responding
- IV or IM epinephrine
-
Antitussive?
Codein--stops cough reflex
-
Nonopiod antitussive?
dextromethorphan--no addictive/altered state properties
-
What is given for exercise induced asthma before the activity?
- Montelukast
- Salmeterol
- CROMOLYN****
-
Expectorant?
MOA?
- Guinefesin
- decrease mucus viscosity
-
Contraindication for Guinfenesin?
chronic cough due to smoking, emphysema, asthma
-
How are diluents administered?
ultrasonic nebulizer
-
Mucolytic?
used when?
- n acetylcysteine
- CF or atelectasis
-
Recombinant DNAse used for CF?
Dornase alfa
-
2 decongestants?
MOA?
- Pseudoephedrine
- phenylephrine
- vasoconstriction via alpha 1
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