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IBD 1
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PANCA
what are the characteristics of this marker
very sensitive for IBD (fewer than 5 % of people that have this are IBD negative)
2/3 UC
1/4 crohns
ASCA
1/2 to 1/3 patients with this have CD. Very specific for CD
OmpC
sensitive for IBD
more specific for CD
C-Bir1
specific for CD
but only present on 50% of patients with crohns
Which marker can predict the chances of having pouchitis.
Panca
Likely because of an increase in the level of chronic pouchitis in PANCA + patients
which marker can predict higher number of surgeries
ASCA
how much does ulcerative colitis reduce fertility
it does not
how much does having uc and having a pouch procedure reduce fertility
80%
In Crohns disease how is fertility affected
pelvic inflammation can lead to fallopian tube scarring.
IgG1 monoclonal antibody that is human murine hybrid
inflimimab
fully human monoclonal antibody
adalimumab
list risk factors for cancer in u/c patients
pan colonic disease
duration of disease
Backwash ileitis
which serum marker tends to predict that crohns disease will be limited to the colon?
PANCA
how much does NOD2/CARD15 gene affect rates of Crohns disease
one copy- 3 fold increas in CD risk
two copies of the gene- 10-40 fold increase
IBD and joint disease
how are they related
usually large joints and asymmetric.
joint problems are more active when bowel sx are active
extraintestinal manifestations of IBD that parallel disease activity
E.nodosum
arthralgias,
uveitis,
and
DVT
extraintestinal manifestations of IBD that don't parallell bowel activity
ankylosing spondylitis.
what serum marker needs to be checked prior to initiating cyclosporin therapy
cholesterol.
the dose needs to be adjusted if serum cholesterol is less than 100
Clinical predictors for pouchitis
extraintestinal manifestations,
backwash ileitis
need for high dose steroids prior to surgery
Lifetime risk of pouchitis in patients with IPAA
50%
Author
jonpnass
ID
115969
Card Set
IBD 1
Description
IBD questions
Updated
2011-11-10T23:27:28Z
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