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Pharm Anti-Inflammatory

  1. NSAIDs essentially block TxA? or PGI?
    inhibition of TxA is more pronounced--thus used to inhibit protein aggregation in MI
  2. What are the eiconosaoids?
    • Prostaglandins
    • Prostacyclins
    • Leukotrienes
    • Thromboxanes
  3. What FA gives rise to Eiconosoids?
    Linoleic
  4. What converst phospholipds to arachidonic acid?
    phospholipase A2
  5. What enzyme converts arachidonic acid to endoperoxides?
    cyclooxygenase
  6. What enzyme converts arachidonic acid to Hydroperoxides?
    Lipo-oxygenase
  7. What drug inhibits Lipooxygenase?
    Zileuton
  8. What drugs inhibits binding of LTD4 to receptors?
    Monetlkaust
  9. What drug inhibits Cyclooxygenase enzyme?
    Reversibly?
    Irriversibly?
    • NSAIDS
    • Aspiring- irriversibly
  10. What inhibits phopholipase A2 enzyme?
    corticosteroids
  11. Role of PGE1?
    • maintainenance of GI mucosa via
    • 1. increasing secretion of GI mucosa
    • 2. decreasing acid secretion
  12. Rx of NSAID induced ulcers?
    Misoprositol
  13. PGF2 analog used for glaucoma?
    Latonoprost
  14. What PGE1 maintains PDA?
    Alprostadil
  15. Which Prostaglandin analog is Abortificient?
    PGE1
  16. PGE2 do what?
    Synthetic analog?
    • Uterine contraction/cervical contraction
    • Dinoprostone
  17. PGF2 does what?
    Synthetic analog?
    • Uterine and BRONCHIAL CONTRACTION
    • Latanoprost
  18. What prostaglandins are elevated in Dysmenorrhea?
    • PGE2
    • PGF2
  19. PGF2 analogs?
    • Dinoprost
    • Carboprost
  20. What Prostaglandin analogs are abortificient?
    • PGE1--Miloprostone
    • PGF2--Carboprost and Dinoprost
  21. Role of PGI2?
    • vasodilation
    • inhibit platelet aggregation
  22. PGI2 synthetic analog used for pulmonary HTN?
    Epoprostenol
  23. What COX activates PGI2?
    Cox2-so cox2 inhibitor i.e celexocib increase platelet aggregation and you get MI
  24. Role of TX2?
    • opposite of PGI2 i.e
    • vasodilation, bronchoconstriction
    • promote platelet aggregation
  25. TxA work thru what g protein secondary signalling molecule?
    PGI2 works thru what g protein secondary signalling molecule?
    • phospholipase c--> IP3-->high Ca---platelet aggregation
    • activated camp..which sequesters Ca--decrease platelet aggregation
  26. Role of LTB4?
    neutrophil chemotaxis
  27. Role of LTA4, LTD4, LTC4?
    • anaphylaxis
    • vasoconstriction
    • bronchoconstriction
Author
Anonymous
ID
115752
Card Set
Pharm Anti-Inflammatory
Description
Pharm Anti-Inflammatory
Updated

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