ADT Exam 2

7%

labeling has to describe evidence and identify specific tests needed for selection and monitoring patients who need the drug

• study of how variant forms of human genes contribute to inter-individual variability in drug response
• right drug for the right patient

• inherited
• monogenic
• observed only with drug challenge
• not rare

• characterization of the genome wide response to small molecular molecules administered with therapeutic intent
• right drug for right disease
• study of how interacting genes determine individual response to drugs

single nucleotide polymorphism

• single nucleotide variation
• includes SNPs, single nucleotide insertion/deletions

• group of SNPs inherited together as a block
• AGT vs GAC

• the defective drug metabolism pathway is responsible for most of the elimination of the drug
• drug displays a NTI

CYP (cytochrome P 450)

2D

2D6

• *4
• *1 is the reference gene

• two inactive forms (alleles) of the CYP2D6 gene
• 1% of asians but overal lower activity than caucasians

• active
• score is 1

• score is 0.5
• some activity

• no activity
• score is 0