-
HSV-1/2
- DS DNA virus
- Nuclear envelope
- LAT-1 - prevents alpha-0 action which causes adecrease in transcription
- Beta genes: enzymes
- Gamma genes: strutural proteins
- Transmission: direct contact
- HSV 1: gingivostomatitis (kids 1-6), labialis, keratoconjuctivitis, encephalitis, eczema
- HSV-2: vulvovaginitis, progenitalis, asceptic meningitis
- Neonatal herpes: high mortality rate
- Dx: clinical, IF, viral isolation
-
VZV
- Chicken pox: primary infection
- inhalation
- incubation: 14-18 days
- mild fever, malaise, headaches, vesicles
- transformation possible
- Shingles: reactivation
- 50% over 50
- pain before vesicles
- Dx: clinical, IF
- prevention: live vaccine
- Tx: supportive, acyclovir
-
CMV
- Nuclear, cytoplasmic inclusion bodies, giant cells
- Congenital: hearing loss, mental retardation, junadice, organomegaly, anemia, low eight, microcephaly
- Imunnosuppressed: CMV pnuemonia
- BM grafts: CMV pnuemonia leading cause of death
- HIV: retinitis, gastroenteritis
- Transmission: cmose contact
- Dx: isolation, EM, PCR
- Heterophil negative mono
- tx: gancyclovir, IVIG
- prevention: vaccine
-
EBV
- Heterophil positive mono (infectious mono)
- African burkitt's lymphoma
- EBNAs, VCA: viral markers
- Transmission: contact
- Disease: low fever, headache, sorethroat, fatigue, night chills, enlarged spleen, atypical lymphocytes
- Complications: laryngeal obstruction, meningitis, splenic rupture
- Dx: CBC (10% downey cells), heterophil positive Ab, VCA Ab
- Tx: acyclovir
|
|
