Lecture

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• DP: alpha 1 vasoconstriction increase DP
• PP: beta 1 increase IS
• HR: beta 1 increased HR overridden by BRR activated by decreased BP

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• DP: beta2 vasodilation is greater than alpha1 vasoconstriction, DP decreases
• PP: beta1 increases IS (MBP stays about the same)
• HR: beta1 increases HR (no BRR)

• DP: activates M3 receptors on the vessels causing vasodilation and decreased DP
• PP: no parasympathetic effect on HR
• HR: M2 decreases HR, but BRR causes increase sympathetic tone to increase HR

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• EPI goes from a pressor to a depressor after alpha1 inhibition

decreases DP b/c EPI has higher affinity for beta2 receptors on VSM

there are more alpha than beta receptors on VSM so at high doses of EPI both alpha and beta receptors are activated and the alpha receptor mediated vasoconstriction leads to an increased DP