Chapter 11

when two different molecules associate or attach to each other

an abnormal sensitivity generally resulting in an allergic reaction

a potentially fatal hypersensitivity reaction producing severe respiratory distress and cardiovascular collapse

an unexpected reaction the first time a drug is taken, generally due to genetic causes

the ability of a substance to cause cancer

when two drugs with similar pharmacological actions result in an effect equal to the sum of the individual effects

when two drugs with similar pharmacological actions produce greater effects than the sum of the individual effects

a drug that antagonizes the toxic effect of another drug

a chronic and potentially fatal liver disease causing loss of function and increased resistance to blood flow through the liver

an inflammation condition of the liver caused by viruses

when elements of ingested nutrients interact with a drug and this affects the disposition of the drug

an obstruction of the bile duct that causes hepatic waste products and bile to accumulate in the liver

a condition in which thyroid hormone secretions are above normal, often referred to as an overactive thyroid

a condition in which thyroid secretions are below normal, often referred to as an underactive thyroid

a field of study which defines the hereditary basis of individual differeces in ADME processes

an unintended side effect of a medication that is negative or in some way injurious to the patient's health

an effect produced when one drug with no inherent activity of its own increased the activity of another drug

a drug bound to a plasma protein is removed when another drug of greater binding potential binds to the same protein

the decrease in hepatic enzyme activity that results in reduced metabolism of drugs

the increase in hepatic enzyme activity that results in greater metabolism of drugs