Lecture 4

The flashcards below were created by user jknell on FreezingBlue Flashcards.

  1. Sensory neurons
    afferent (into CNS)
  2. Motor Neurons
    efferent (instructions from CNS)
  3. Effects of Sympathetic Division
    "fight or flight"

    • increase HR
    • increase cardiac contractility
    • vasodilate skeletal muscle (increase blood flow)
    • vasoconstriction in viscera/skin (decrease blood flow)
    • Bronchodilation
    • Inhibit GI and urinary tracts
    • Sweating
    • Piloerection
    • Mydriasis (dilation)
    • Accomodation for far vision
  4. Effects of Parasympathetic Division
    "rest and digest"

    • -decrease HR
    • -decrease cardiac contractility
    • -bronchoconstriction
    • -Stimulation of GI and urinary tracts
    • -miosis (constriction)
    • -accomodation for near vision
  5. Systems only under Sympathetic control
    • -most blood vessels
    • -sweat glands
    • -pilomotor muscles
    • -adrenal medulla
  6. Systems predominantly controlled by Parasympathetic Division
    • -GI tract
    • -Urinary tract
    • -eye
  7. Adrenal Medulla
    • -secretes EPI and small amounts of NE into blood
    • -activated during 'fight or flight'
    • -innervated by thoracolumbar cord
  8. Termination of ANS NT actions
    • 1. Enzyme inactivation (ACh by AChE)
    • 2. Reuptake by presynaptic fiber (NE uptake by NET)
    • 3. Diffusion away from junction
    • 4. Uptake by extraneuronal sites
  9. Cholinergic Receptors
    • 1. Nicotinic (ligand gated ion channels)
    • -NN: on all ANS post-ganglionic neuron somas
    • -NM: on SKM

    • 2. Muscarinic (GPCR)
    • -M1 (Gq): on somas of postganglionic neurons in ANS ganglia
    • -M2 (Gi): on heart
    • -M3 (Gq): on smooth muscle and glands, on VSM (non innervated)
  10. Adrenergic Receptors
    • 1. alpha
    • -a1 (Gq): smooth muscle, eye, pilomotor, sphincters of GI and urinary tract
    • -a2 (Gi): a little on smooth muscle, in the CNS, on sympathetic and parasympathetic postganglionic fibers

    • 2. beta
    • -b1 (Gs): heart (SA, AV node, atria, ventricles), kidney (granular cells)
    • -b2 (Gs): smooth muscle (vascular, bronchial, GI, ciliary muscle)
Card Set
Lecture 4
Lecture 4: intro to autonomic pharmacology: Anatomy and physiology of the ANS
Show Answers