Intro to Pharmacology

the effect of drugs on the body

the effect of the body on drugs

• 
• Kd = k-1/k1

• the drug concentration at which the effect is 1/2 of the maximum
• 

• -equilibrium dissociation constant
• -drug concentration at which receptor occupancy is 1/2 maximum

• -fractional saturation
• RO = DR/Rtotal = DR/R+DR

when D = Kd then R = DR and DR/Rtotal = 0.5

Has only a partial response (due to shorter occupancy time)

Binds the R and causes a decreased basal response

• -binds the same site as the Drug
• -if you increase the concentration of the drug you can still have maximal signaling
• 
• 

• -binds to a different site on the receptor, the drug binds it's normal site but can't have maximal signaling
• 
• 
• Kd remains unchanged but maxiumum response is decreased by 1/(1+I/Ki)

binds to a separate site but modulates the ability of the agonist to bind

Drug that antagonized the effect of another druge by inducing an opposing physiological response

• irreversible binding
• -law of mass action does not apply

binds to site independent of agonist binding site and enhances the activity of the agonist

• the does that causes a given effect
• -the most potent has the lowest EC50 (A)
• 

• the dose that gives the maximal response (B, C, D)
• 

mean effective does: produced effect in 50% of patients in a population

mean lethal dose

LD50/ED50