-
Fed
- Dephosphorylated
- Glycogen synthase activated
- PFK1 inactive
-
Fasting
- Phosphorylated
- Glycogen synthase inactivated
- PFK1 activated
-
Commited step of glycolysis
- Fructose 6 phosphate -> fructose 1,6 bisphosphate by phosphofructokinase 1 (PFK1)
- PFK 1 is inactivated in FED state, preventing glycolysis and favoring glycogenesis
-
Step 1
- Glucose -> Glucose 6-phosphate
- Enzyme: hexokinase/glucokinase
-
Step 2
Glucose 6-phosphate -> fructose 6-phosphate
-
Step 3
- Fructose 6-phosphate -> fructose 1,6-bisphosphate
- Enzyme: PFK1
- Point of no return!
- Requires 1 ATP
-
Step 4 (Splitting phase)
Fructose 1,6-bisphos -> dihydroxyacetone phos and glyceraldehyde 3-phos
-
Step 5 (produces NADH)
Glyceraldehyde 3-phos -> 1,3 hisphosphoglycerate
-
Step 6 (produces 2 ATP/glucose)
1,3 bisphosphoglycerate -> 3- phosphoglycerate
-
Steps 7
Reversible isomerization occurs
-
Step 8
Reversible removal of an OH produces PEP,
-
Step 9 (produces 2 ATP/glucose)
- PEP -> pyruvate
- Enzyme: pyruvate kinase
-
Anaerobic glycolysis
- Produces lactate
- Burns 2 NADH gained previously
-
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