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Define analgesics. Example? opioid or non-opioid?
- pain killers, pain relievers
- acetaminophen aka tylenol
- non-opioid
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Define opioid.
an analgesic that relieves pain by acting on the CNS binding to opioid receptors; narcotics
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Define non-opioid. example?
non narcotic; acetaminophen (tylenol); do not bind to opioid receptors
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What are the types of drugs used for pain management?
- Analgesics (opioid or non opioid)
- NSAIDs
- Steroids
- Anti-depressants (chronic pain)
- anti-convulsants (neuropathic pain)
- Muscle relaxers
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What are the 3 receptors of opioid receptors? Which one is the most important? What are the SE's?
- Mu, Delta, and Kappa
- Mu: constipation, addiction, repiratory depression
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what is the action of opioid analgesics?
Inhibition of synaptic transmission. Decreased NT release in presynaptic and blocked receptors in postsynaptic
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What are the different opioid classifications when it comes to opioid receptors? Describe.
- Agonists: high receptor affininity especially for Mu
- Mid to Mod agonists: for mid to mod pain (weak opioids
- mixed agonists and antagonists: safest (less respiratory depression and less pontential for abuse); SE psychotropic affects
- antagonists: completely blocks opioid receptors; used to treat overdoes and addiction
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What are the problems using opioids?
- Addiction
- Physical dependency
- tolerance
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Opioid SEs
sleepy, moody, slowing mental process, respiratory depression, GI (nausea/constipation)
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morphine....type of drug? kind of receptor?
- opioid analgesic
- strong agonists
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demoral...type of drug? kind of receptor
- opioid analgesics
- strong agonists
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dilaudid...type of drug? kind of receptor?
- opioid analgesics
- strong agonists
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fentanyl...type of drug? kind of receptor?
- opioid analgesics
- strong agonists
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codiene...type of drug? kind of receptor?
- opioid analgesics
- mid to mod agonists
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hydrocodone (percoset)...type of drug? kind of receptor?
- opioid analgesics
- mid to mod agonists
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oxycodone (oxycontin)...type of drug? kind of receptor?
- opioid analgesics
- mid to mod agonists
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What is the function of NSAIDs?
- decrease inflammation
- promote analgesia
- reduce fever
- anticoagulation
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aspirin, motrin, advil, nuprin, and mobic are ____.
NSAIDs
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What is COX
an enzyme that is needed to convert the precursor to prostaglandin
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