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A hypothesis that living organisms arise from nonliving matter
Spontaneous generation
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disease causing microbe
Germ
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organisms that are too small to be seen by the unaided eye.
Microbe
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All living things are composed of cells and come from preexisting cells
Cell Theory
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Keeps microbes in but air out - invented by Pasteur
S-shaped flask
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Experimental steps t prove that a specific microbe causes a specific disease.
Koch's postulates
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established the system of scientific nomenclature.
Linnaeus
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Reported that living things were composed of little boxes of cells (which were monks rooms)
Robert Hooke
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Descrived lice microorganisms that he ovserved in teeth scrapings, rain water, feces, etc.
Antoni van Leeuwenhoek
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Said cells arise from preexisting cells
Rudolf Virchow
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Demonstrated that micro organisms are present in the air
Louis Pasteur
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Advocated hand washing to prevent transmission of puerperal fever from one OB patient to another
Ignaz Semmelwise
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Proved that a bacterium causes anthrax and provided that experimental steps to prove that a specific microbe causes specific diseases.
Robert Koch
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Inoculated a person with cowpox virus. Ther person was then protected from small pox
Edward Jenner
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Developed a synthetic arsenic drug, salvarsan, to treat sphilis
Paul Ehrlich
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Discovered the first antibiotic.
Alexander Flemming
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the smallest quantity of an element that can take part in a chemical
reaction
atom
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The smallest particle of a substance that retains the chemical and
physical properties of the substance and is composed of two or more
atoms
molecule
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Any of a group of complex compounds found in all living cells and
viruses, composed of purines, pyrimidines, carbohydrates, and phosphoric
acid. Nucleic acids in the form of DNA and RNA control cellular
function and heredity
Nucleic acid
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are essential for cell structure and function
proteins
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Provide energy by releaseing bond energy and carbon to build new molecules. E.g. Sugars
Carbohydrates
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Store large amounts of energetic bonds efficiently. E.g. Fats
Lipids
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the image from the objective lens is magnified again by the ocular lens
compound microscope
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classifies bacteria into gram-pos and gram-neg bacteria
Gram stain
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the ability of a microscope, telescope, or other optical instrument to
produce separate images of closely placed objects
resolving power
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To treat (specimens for the microscope) with a reagent or dye that makes
visible certain structures without affecting others
differential stain
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one circular chromosome, not in the membrane
no organelles
Peptidoglycan cell walls
binary fission
Prokaryotes
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Paired chromosomes, in nuclear membrane
Organelles
Polysaccharides cell walls
mitotic spindle
Eukaryote
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membrane is as viscous as olive oil
Proteins move to function
Fluid mosaic model
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Movement of a solute from an area of high concentration to an area of low concentration
Simple diffusion
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Solute combines witha transporter protein in the membrane
Facilitative diffusion
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a stubstance require a transporter protien and ATP
Active Transport
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water moves into the cell and may cause the cell to burst if the wall is weak or damaged
Hypotonic Solution
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water moves out of the cell causing its cytoplasm to shrink
Hypertonic solution
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The sugar coat, made of polysaccharides
Glycocalyx
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Resting cells, that are resistant to desiccation heat and chemicals
Endospores
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Allow attachment
fimbraie
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Are used to transfer DNA from one cell to another. AKA bacterial sex
Pili
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-
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The energy releasing processes
Catabolism
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The energy using processes
Anabolism
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when a protein can no longer function
Denatured
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The final electron acceptor in the electron transport chain is colecular oxygen. (Uses Oxygen0
Aerobic respiration
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The final electron acceptor in the electron transport chain is not O2, is part of the kerbs cycle. (no oxygen)
Anaerobic respiration
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releases energy for oxidation of organic molecules,.
Does NOT require oxygen
Fermentation
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Lactic acid, ethanol, propionic acid, etc
End products of fermentation
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microbial contamination
sepsis
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the absence of significant contamination
Asepsis
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removal of all microbial life
Sterilization
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removal of pathogens
Disinfection
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lower microbial counts on eating utensils
Sanitization
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A chemical agent, such as a pesticide, that is capable of destroying
living organisms.
Biocide
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An agent, such as a chemical or
biological material, that inhibits bacterial growth.
bacteriostatic
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Depends on: number of microbes, environment, them of exposure, and microbial characteristics
Effectiveness of antimicrobial treatment
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How does alchohol used as a disinfectant
Denatures proteins
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a segment of DNA that encodes a functional product, usually a protein
Gene
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The process by which messenger RNA is synthesized from a DNA template
resulting in the transfer of genetic information from the DNA molecule
to the messenger RNA.
Transcription
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The process by which messenger RNA directs the amino acid sequence of a
growing polypeptide during protein synthesis.
Translation
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To block (transcription of a gene) by combination of a protein to an
operator gene.
repressible
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To cause an increase in the transcription of the RNA of (a gene).
inducible
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Enzymes are expressed at a fixed rate, always produced
Constitutive
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A change in genetic material
Mutation
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The alteration of a bacterial cell caused by the transfer of DNA from
another bacterial cell, especially a pathogen.
Transformation
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The natural formation in offspring of
genetic combinations not present in parents, by the processes of
crossing over or independent assortment.
recombination
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Sharing of genetic information
conjugation
-
The science of classifying organisms
Taxonomy
-
Archaea, Bacteria, and Eukarya are part of the?
Three Domain System
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concerns the origins of mitochondria and plastids (e.g. chloroplasts),which are organelles of eukaryotic
cells. According to this theory, these organelles originated as separate prokaryotic organisms which were taken inside the cell as endosymbionts.
Endosymbiotic Theory
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A catchall for eukaryotic organisms that do not fit other kingdoms
Protista
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a key used to identify a plant or animal in which each stage presents
descriptions of two distinguishing characters, with a direction to
another stage in the key, until the species is identified
Dichotomous Key
-
-
A branching, treelike diagram in which the endpoints of the branches
represent specific species of organisms. It is used to illustrate
phylogenetic relationships and show points at which various species have
diverged from common ancestral forms.
cladogram
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an organism that obtains its energy from the oxidation of organic
compounds
chemoheterotroph
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the study of fungi
mycology
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Any of various fungi that often cause disintegration of organic matter.
Mold
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A type of body found among plants and fungi that is not differentiated
into roots, stems, or leaves
thallus
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Any of the threadlike filaments forming the mycelium of a fungus.
hyphae
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unicellular fungi, fission divide symmetrically, budding dicide asymmetrically
yeasts
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Existing or occurring in two distinct forms;
dimorphic
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an organism that is formed by the symbiotic association of a fungus and
an alga or cyanobacterium and occurs as crusty patches or bushy growths
on tree trunks, bare ground, etc. Lichens are now classified as a phylum
of fungi
lichen
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unicellular, chemoheterotrophs, vegatatie for mis trophozoite, asexual reproducion and sexual, produce cysts
protozoa
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Eukaryotic, multicellular animals, kingdom; animalia (flat worms, round worms)
Helminths
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the host in which the sexual reproduction of a parasite takes place
definitive host
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a host that is used by a parasite in the course of its life cycle
intermediate host
-
what is 200 x 20nm?
prion
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what is 10,000 nm
human red blood cell
-
How can you grow viruses in a laboratory?
in living animals and in embryonated eggs
-
Phage causees lysis and death of host cell, virus replicates unrestrictedly
lytic cycle
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Prophage DNA incorporated in host DNA
Lysogenic cycle
-
viruses attach to cell membrane
attachment
-
nucleic acid and capsid proteins assemble
maturation
-
the study of disease
pathology
-
the study of the cause of disease
etiology
-
the developement of disease
Pathogenesis
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colonization of the body by pathogens
infection
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an abnormal state in which the body is not functioning normally
disease
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Permanently colonized the host, such as the intestines
normal microbiota
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the relationship between two organisms, such as a human and bacteria
symbiosis
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one organism is benefited and the other is unaffected
commensalism
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both organisms benefit
mutualism
-
one organism is benefited at the expense of the other
parasitism
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a change in body function that is felt by a patient as a result of disease
symptom
-
a change in a body that can be measured or observed as a result of disease
sign
-
a specific group of signs and symptoms that accompany a disease
syndrome
-
a disease that is spread from one host to another
communicable
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a disease that is easily spread from one host to another
contagious
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a disease that is not transmitted from one host to another
noncommunicable
-
fraction of a population having a specific disease at a given time
prevalence
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disease that occurs occasionally in a population (west nile)
sporadic
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disease constatnly present in a population
endemic
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diesease acquired by many hosts in a given area in a short time
epidemic
-
worldwide epidemic
Pandemic
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disease that symptoms develope rapidly
acute
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disease that developes slowly
chronic
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disease witha period of no symptoms when the patient is inactive
latent
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pathogens are limited to a small area of the body
local infection
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an infection throughout the body
systemic
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systemic infection that began as a locan infection
focal
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bacteria in the blood
baceremia
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growth of bacteria in the blood
septicemia
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hospital accuired infection
nosocomial
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portals of entry
mucous membranes, skin, parenteral route
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Infectious dose for 50% of the test population
ID 50
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Lethal Dose (of a toxin) for 50% of the test population
LD 50
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Portals of exit
Respiratory tract, gastrointestinal tract, genitourianary tract, skin, and blood
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Lack of resistance to a disease
susceptibility
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ability to ward off disease
immunity
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defenses against any pathogen
innate immunity
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immnity, resistance to a specific pathogen
adaptive immunity
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ingestion of microbes or particles by a cell, performed by phagocytes
Phagocytosis
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A substance that causes the body to produce specific antibodies or sensitized T cells
Antigen (Ag)
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Proteins made in response to an Antigen; can combine with that Antigen
Antibody (Ab)
-
has become a widely accepted model for how the immune system responds to infection
and how certain types of B and T lymphocytes are selected for destruction of specific antigens
invading the body.
Clonal Selection
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inoculation of cowpox into skin (cross reactivity)
vaccination
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resluts when most of a population is immune to a disease
herd immunity
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Diphtheria and tetanus toxoids and accellular pertussis combination
vaccine.
DtaP
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vaccine that is absolutely not alive and can not replicate
inactive vaccine
-
a vaccine that is alive, but changed a little
attenuated virus
-
What are the four harmful immune responses?
Allergies, Transplant rejection, Autoimmunity, Superantigens
-
A glycoprotein on the surface of helper T cells that serves as a
receptor for HIV.
CD4
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A chemokine receptor; defects in its structure caused by genetic
mutation cause the progression of AIDS to be prevented or slowed.
CCR5
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In what fluids can HIV be transmitted
- *Sexual contact
- *Breast milk
- *Transplacental infection of fetus
- *Blood-contamination
- *Organ Transplants
- *Artificial insemination
- *Blood transfusion
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A substance produced by a microbe that, in small amounts, inhibits another microbe
Antibiotic
-
ToxDose50/EffDose50
Therapeutic indes
-
an antibiotic that is effective against a wide range of infectious
microorganisms.
Broad spectrum
-
An agent that destroys bacteria
bactericidal
-
preventing bacteria from growing and multiplying but possibly not
killing them.
bacteriostatic
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A drug that is similar to the drug from which it is derived.
analogs
-
Chloramphenicol, Aminoglycosides, Tetracyclines, Quinolones and fluoroquinolones
Broad Spectrum antibiotics
-
inhibits DNA Synthesis (malaria)
Cholroquine
-
Damages DNA (entamoeba, trichomonas)
Metronidazole
-
alters membrane permeability (flatworms)
Praziquantel
-
inhibits nutrient absorbtion (intestinal round worms)
Mebendazole
-
Paralyzes worm (intestinal round worm)
Ivermectin
-
cytosin analog interferes with RNA synthsis
Flucytocine
-
used for superficial mycoses
Griseofulvin
-
Used for athletes foot; action unknown
Tolnaftate
-
4 recomendations by the CDC for "safer sex"
- Don't have sex
- Use condoms
- Be faithful
- Talk frankly with our doctor or nutse about your sex partener about any STDs you or your partner have had
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A disease which can be spread from animals to humans.
zoonotic
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An inanimate object or substance, such as clothing, furniture, or soap,
that is capable of transmitting infectious organisms from one individual
to another.
fomite
-
The branch of medicine that deals with
the study of the causes, distribution, and control of disease in
populations.
epidemiology
-
any abnormal condition that follows and is the result of a disease,
treatment, or injury, such as paralysis after poliomyelitis, deafness
after treatment with an ototoxic drug, or scar formation after a
laceration.
sequelae
-
Cystitis is defined as inflammation of the urinary bladder.
cystitis
-
an inflammation of the kidney and upper urinary tract that usually
results from noncontagious bacterial infection of the bladder
pyelonephritis
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