-
Which of the following condition is not associated with high
incidence of leukemia?
- a.
- Paroxysmal nocturnal hemoglobinuria
-
The M:E ratio in chronic myelocytic leukemia is usually:
-
Abnormalities found in erythroleukemia include:
- c.
- Megaloblastoid development
- d.
- Increased erythrocyte survival
-
Neutropenia is not usually associated with:
-
Auer rods are most likely present in which of the following?
- a.
- Chronic myelocytic leukemia
- b.
- Myelofibrosis with myeloid metaplasia
- d.
- Acute myelocytic leukemia
-
In an uncomplicated case of infectious mononucleosis, which of the following cells are affected?
-
The atypical lymphocyte seen in the peripheral smear of patients with infectious mono is probably derived from which of the following?
-
Which of the following cells is the atypical lymphocyte seen on the peripheral blood smear of patients with infectious mononucleosis?
-
The disease most frequently present in patients with
atypical lymphocytosis and persistently negative tests is:
- b.
- Cytomegalovirus (CMV) infection
- c.
- Herpes virus infection
-
Which of the following is associated with pseudo-Pelger-Huet anomaly?
- b.
- Iron deficiency anemia
- d.
- Chediak-higashisyndrome
-
Increased numbers of basophils are often seen in:
- b.
- Chronic myelocytic leukemia
- c.
- Chronic lymphocytic leukemia
- d.
- Erythroblastosis fetalis
-
In chronic myelocytic leukemia , blood histamine concentration tend to reflect the
- a.
- Number of platelets present
- b.
- Serum uric acid concentrations
- c.
- Number of basophils present
- d.
- The total number of granulocytes
-
Biochemical abnormalities characteristic of polycythemia vera include
- a.
- Increased
- serum B12 binding capacity
- d.
- Decreased leukocyte alkaline phosphatase activity
-
50%-90% myeloblasts in a peripheral blood in typical of which of the following?
- a.
- Chronic myelocytic leukemia
- b.
- Myelofibrosis with myeloid metaplasia
- d.
- Acute myelocytic leukemia
-
The M:E ratio in acute myelocytic leukemia is usually
-
Which of the following is most closely associated with
chronic myelomonocytic leukemia?
- a.
- Philadelphia chromosome
- b.
- Disseminated intravascular coagulation
-
The absence of intermediate maturing cells between the blastand mature neutrophil commonly seen in acute myelocytic keukemia and myelodysplastic syndromes is called:
-
Which of the following is most closely associated with
chronic myelogenous leukemia?
- b.
- Disseminated intravascular coagulation
- d.
- Philadelphia chromosome
-
A block in the differentiation or maturation of, and an
accretion of immature hematopoietic progenitors is a hallmark of:
- a.
- Chronic lymphocytic leukemia
- b.
- Myeloproliferative disease
- d.
- Acute myelogenous leukemia
-
All stage of neutrophils are most likely to be seen in the peripheral blood of a patient with:
- a.
- Chronic myelocytic leukemia
- b.
- Myelofibrosis with myeloid metaplasia
- d.
- Acute myelocytic leukemia
-
All of the following conditions are myeloproliferative disorders except:
- a. Myelocytic leukemiab.
- Lymphocytic leukemiac.
- Polycythemia verad.
- Idiopathic thrombocythemia
-
A patient has a tumor that concentrates erythropoietin. He is most likely to have which of the following types of polycythemia?
- b.
- Polycythemia, secondary to hypoxia
- c.
- Benign familial polycythemia
- d.
- Polycythemia associated with renal disease
-
Which of the following types of polycythemia is most often associated with emphysema?
- b.
- Polycythemia, secondary to hypoxia
- c.
- Relative polycythemia associated with
- dehydration
- d.
- Polycythemia associated with renal disease
-
Hemorrhage in polycythemia vera is the result of :
- a.
- Increased plasma viscosity
- b.
- Persistent thrombocytosis
- c.
- Splenic sequestration of platelets
- d.
- Abnormal platelet function
-
A patient diagnosed with polycythemia vera 5 years ago now has a normal hematocrit, decreased hemoglobin and microcytic, hypochromic red
cells. What is the most probable cause for the current blood situation?
-
A patient has been treated for polythemia vera for several years. His blood smear now shows:
Oval macrocytes
Howell-Jolly bodies
hypersegmented neutrophils
large, agranular platelets
The most probable cause of this blood picture is:
- c.
- Dietary B12 deficiency
-
In infectious mononucleosis, lymphocytes tend to be:
- a.
- Small with little cytoplasm
- d.
- Enlarged and indented by surrounding structures
-
In comparison to malignant lymphoma cells, reactive
lymphocytes
- a.
- Have a denser nuclear chromatin
- b.
- Are known to be T cells
- c.
- Have more cytoplasm and more mitochondria
- d.
- Are morphologically more variable throughout the
- smear
-
Which of the following is true of acute lymphoblastic
leukemia?
- a.
- Occurs most commonly in children 1-2 years of
- age
- b.
- Patient is asymptomatic
- c.
- Massive accumulation of primitive lymphoid-appearing cells in bone marrow occurs
- d.
- Children under 1 year of age have a good
- prognosis
-
A 50 year-old woman who has been receiving busulfan for three years for chronic myelogenous leukemia become anemic. Laboratory tests
reveal:
Thrombocytopenia
Many peroxidase-negative blast cells in the peripheral blood
Bone marrow hypercellular in blast transformation
Markedly increased bone marrowTdT
which of the following complications is this patient most likely to have?
- a.
- Acute lymphocytic leukemia
- b.
- Acute myelocytic leukemia
- c.
- Acute myelomonocytic leukemioa
-
The most common form of childhood leukemia is:
-
Chronic lymphocytic leukemia is defined as a(n):
- a.
- malignancy of the thymus
- b.
- accumulation of prolymphocytes
- c.
- accumulation of hairy cells in the spleen
- d.
- accumulation of monoclonal B cells with a block
- in cell maturation
-
Which of the following is not a characteristic usually
associated with hairy cell leukemia?
- b.
- Mononuclear cells with ruffled edges
- d.
- Increased resistance to infection
-
Morphologic variants of plasma cells do not include:
-
Of the following, the disease most closely associated with
cytoplasmic granule fusion is:
- a.
- Chediak- higashi syndrome
-
Which of the following anomalies is an autosomal dominant disorder characterized by irregularly-sized inclusions in polymorphonuclear neutrophils, abnormal giant platelets and often thrombocytopenia?
- a.
- Chediak- higashi syndrome
-
Of the following, the disease most closely associated with granulocyte hyposegmentation is:
- a.
- Chediak- higashi syndrome
-
Which of the following cell types is characteristic of
Pelger-Huet anomaly is the:
-
Which of the following is associated with Chediak-Higashi syndrome?
- a.
- Membrane defect of lysosomes
- b.
- Dohle bodies and giant platelets
-
Which of the following is associated with Alder-Reilly
inclusion?
- a.
- Membrane defect of lysosomes
- b.
- Dohle bodies and giant platelets
Mucopolysaccharidosis
-
Which of the following is associated with May-Hegglin
anomaly?
- a.
- Membrane defect of lysosomes
- b.
- Dohle bodies and giant platelets
-
A differential was performed on an asymptomatic patient. The differential included 60% neutrophils; 55 of which had 2 lobes and 5 had 3 lobes. There were no other abnormalities. This is consistent with which of the following anomalies?
-
The cytoplasmic abnormality of the white blood cell of
Alder-Reilly anomaly is found in the :
-
Of the following , the disease most closely associated with mucopolysacharidosis is:
- b.
- Chediak-higashi syndrome
-
Of the following, the disease most closely associated with
glucocerebrosidase deficiency is:
- b.
- Chediak-higashi syndrome
-
Of the following, the disease most closely associated with
pale blue inclusion in granulocytes and giant platelets is:
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