-
ACE inhibitors
'prils'
-inhibit synthesis of Ang II
-
Captoptril
Mechanism: inhibit ACE, decreased synthesis of Ang II (also inhibits KKS)
Indictations: HTN, HF, LV systolic dysfunction, MI, Renal protection
Adverse Effects: cough, angioedema (rare), hypotensin, hyperkalemia, decreased renal function in patients with renal problems
Other: contraindicated in pregnancy, prodrug converted in liver
-
AT1 receptor blockers (ARBs)
- -'sartans'
- -block AT1 receptors
-
Losartan
Mechanism: blocks AT1 receptors
Indications: HTN, HF/LV systolic dysfunction, MI, renal protetction
Adverse Effects: hypotension, hyperkalemia, decreased renal function in patients with renal problems
Other: contracindicated in pregnancy
-
Direct renin inhibitors
-'kirens'
-Inhibit renin, decreased Ang II synthesis
-
Aliskiren
Mechanism: inhibits renin, leading to decreased Ang II synthesis
Indications: HTN
Adverse Effects: mild GI symptoms
Other: contraindicated in pregnancy
-
Kallikrein inhibitors
Mechanism: inhibit plasma kallikrein
Indications: hereditary angioedma (acute attacks)
Adverse Effects: acute hypersensitivity reactions (including anaphylaxis), injection site reactions, headache, fatigue, nausea, diarrhea
-
B2 receptor antagonists
Mechanism: blocks B2 receptors
Indications: Hereditary angioedema (acute attacks)
Adverse Effects: injection site reactions, fever, dizziness, rash, increase hepatic enzyme levels
-
ET receptor antagonists
-'sentans'
-Bosentan
-
Bosentan
Mechanism: blocks ET receptors
Indications: Pulmonary HTN
Adverse Effects: Hepatotoxicity, headache, nasopharyngitis, flushing, peripheral edema
Other: contraindicated in pregnancy, must monitor LFTs, restricted distribution program
-nonselective
-
SP Inhibitors
Mechanism: block NK1 receptors
Indications: chemotherapy-induced/post op nausea and vomiting
Adverse Effects: fatigue, dizziness, diarrhea
-
Synthetic BNP
Mechanisms: stimulates NPRs (vasodilation, natriuresis)
Indications: CHF (acute)
Adverse Effects: hypotension, dizziness
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