-
Meta. acidosis inhibits trans. system as Na and H ions enter cells at the expense of?
increased K excretion
-
this stimulates cellular retention of K
Alkalosis
-
Caused by diuretics, steroid therapy, renal tubular disease, vomiting, diarrhea, malnutrition, trauma. Symps. muscle weakness, paralysis, ECG abnormalities, supraventricular, arrhythmias, circulatory failure, cardiac arrest.
Hypokalemia
-
Hypokalemia treat, involves replacement of K often w/ Cl. Admin of IV K must be cautious because?
cardiac muscles are sensitive to exracellular K
-
caused by chronic renal disease, hemorrhage, tissue necrosis, nonsteroid anti-inflammatory drugs, ACE inhibitors, cyclosporine, K sparing diuretics. Sympts. ECG changes, ventricular arrhythmias, cardiac arrest.
Hyperkalemia
-
Hyperkalemia treatment involves the restriction of
K intake
-
Norm serum Ca is
4.5-5.25 mEq/L
-
Ca is maintained by humral factors such as?
Vitamin D and parathyroid hormone
-
is an important mediator of neuromuscular function and cellular enzyme processes. most of it is in the bones
Ca
-
Ca is carried in the blood three ways;
ionized, pretien-bound, and complex
-
percent Ca2+ is nonionized and bound to plasma albumin
40
-
percent Ca2+ in anion complex
10
-
percent Ca2+ is ionized
50
-
is physiologically active in processes such as enzyme activity, blood clotting, neuromuscular irritability, and bone calcification
Ca2+
-
Acidemia does what to Ca2+ in serum?
increases
-
Alkalemia does what to Ca2+ in serum
decreases
-
caused by hypoparathyroidism, pancreatitis, renal failure, and trauma. Sympts. fatigue, depression, muscle weakness, anorexia, nausea, vomiting, constipation
Hypocalcemia
-
causes hyperthyroidism, hyperparathyroidism, metastatic bone cancer, sarcoidosis. Sympts. fatugue, depression, muscle weakness, anorexia, vomiting, and constipation
Hypercalcemia
-
If serum Ca2+ rises above 17mg/L (8.3mEq/l) what may occur
death
-
norm serum Mg2+
1.7-2.1 mg/L
-
fatty acids and excess phosphates impair
Mg2+ uptake
-
what percentage of Mg2+ is ionized or bound to other ions?
80
-
What percentage of Mg2+ is bound to proteins?
20
-
this is important for muscle function, neural conduction, particulary in the cardiac conduction system.
Mg2+
-
causes inadequate intake/impaired absorbtion of Mg2+, pancreatitus, alcoholism. Sympts. muscle weakness, irritability, tetany, ECG changes, arrhythmias, delirium, and convulsions.
Hypomagnesemia
-
causes dehydration, renal insufficiency, tissue trauma, lupus erythematosus. Sympts. ECG changes, hyperkalemia,cardiac arrest, respiratory muscle paralysis, and diaphragmatic weakness
Hypermagnesemia
-
Norm Phosphate serum level
1.2-2.3 mEq/L
-
what percentage of the body HPO42- is contained in bone and teeth
80-90
-
what percentage of phosphate is combined with proteins, carbs, and lipids in muscle tissue and blood, and the rest is incorporated into complex organic compounds.
10-17
-
is the main anion in the cells.
organic phosphate
-
plays a primary role in the metabolism of cellular energy, being the source from which ATP is sythesized
inorganic phosphate
-
Phosphate is the main urinary buffer for titratable acid excretion in/
Acid-Base homeostasis
-
Causes starvation, malabsorption, hyperparathyoidism, hyperthyroidism, uncontrolled diabetes mellitus. Sympts. diaphragmatic weakness
Hypophosphatemia
-
cases are endocrine disorders, acromegaly, chronic renal insufficiency, acute renal failure, tisse trauma. Sympts are minimal
Hyperphosphatemia
-
Normal HCO3 level in arterila blood.
22-26mEq/L
-
is the primary means for transporting CO2 from the tissues to the lungs.
HCO3
-
In acid base disorders, ____ regulate HCO3- levels to maintain near normal pH
the kidneys
-
In normal persons more than 80% of blood HCO3- is reabsorbed in _______ of the kidneys
the proximal tubules
-
In respiratory acidosis kidneys.....
retain or produce HCO3-
-
In repiratory alkalosis kidneys......
get rid of HCO3-
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