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What is diff in terms of phosphate homeostasis with PTH and Vitamin D?
- PTH--increases Phosphate exretion in kidney
- Vitamin D-increases phosphate absorption in intestine
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4 PTH function
- ca and po4 resorption
- increase po4 exrection in kidney
- increases ca absorption in DCT
- upregulate alpha 1 hydroxylase--which activated VITAMin D which reabsorbs ca from intestine
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SIADH tx
- demeclocycline
- Coniviptan --blocks V1 and V2
-
ADH and oxytocin are produced where?
supraoptic and paraventricular nuclei
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Tx for pit. adenoma
- surgery
- radiation therapy
- bromocriptine--stop prolactin
- octerotride--somatostatin analog block GH
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In case of hypo. ant. pit. what hormone goes down first?
Which one should be treated?
- GnRH--sexual dysfunction ensues
- ACTH def. should be treated with cortisol to maintain sugar level and BP
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TX for Lithium induced DI?
Amelioride
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Tx for DI?
Hydrochlorothiazide
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Somatostatin has 2 roles in two diff places? WHat releases it?
- hypothalamus--blocks GH and TSH
- D cells of pancreas- stop insulin, glucagon, pancreatic enzymes
- GI-block gastrin, pepsinogen
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What effect does lithium have on Na level ?
decreases it via displacement
-
3 Drugs for Prolactinemia?
- ergot derived:
- Bromocriptine
- Pergolide
- Cerbergoline
-
GH for dwarfism?
Somatotropin
-
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2 Tx for neurogenic DI?
- desmopressin-releases vwf factor from endothelium
- vasopressin
-
ENtrapment neuropathy?
Cause?
- Carpal Tunnel
- GH/Pregnancy
-
3 Strategies for post menopausal osteoporosis?
- Bisphosphonates
- Relexifine
- Somatotropin
-
Primary cause for Hyperparathyrodism?
Secondary?
- Adenoma
- low ca---> high PTH
-
Coniviptan blocks which receptors?
Tolvaptan?
-
What ADh receptor does Vasoconstriction?
V1
-
Measurment of what tells you about levels of GH?
Somatomedin c /IGF-1
-
Excess GH production in Kids?
Adults?
- kids--gigantism
- adults--acromegaly
-
In normal pts, glucose has what effect on GH?
- low glucose high GH
- high Glucose, low GH
-
GH receptor antagonist for gigantism?
Pegvisomant
-
Drug to diagnose ACTh deficiency?
Metyrapone--inhibit cortisol production which should increase acth
-
Somatostatin analog for acromegaly, carcinoid, glucagonoma, gastrinoma?
Octeotride
-
5 Releasing HR from Hypothalamus?
-
How to diagnose GH deficiency?
give insulin--> low glucose--> should increase GH
-
3 Causes for Hypo. Ant. Pit?
- inflamation-encephalitis, sarcoidosis
- post partum hemorrhage
- pit. apoplexy--hemorrhagic infact due to pit. adenoma
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