-
Deferoeximne
IM and IV, low oral avaliability
-
Ferrous Salts
- Iron deficiency treatment - oral prepration
- Ferrous Gluconate better than Ferrous sulfate > Ferrous fumarate
-
Free Ferric Fe
- Iron deficiency - IV/MI (parenteral) prepration
- for those who can't absorb oral ferrous
- or renal disease on EPO administration, require larger dosage
- Toxicity exists
-
Iron dextran
Ferric oxyhydroxide
-
Deferoxamine
- Iron chelator
- low oral avaliability - IM/IV administration
- Removes Fe from hemosiderin, ferritin and Tf but not Hb or cytochroms
- Yay, its sooo magical
- Iron poisoning and Fe overlaod
-
Deferasirox
- Iron chelator
- Good oral avaliability
- Chronic iron overload (frequent blood transfusions)
- it doesn't work as well but at least you can take it orally
-
Schilling test
- pernicious anemia associated B12 deficiency vs. distal ileum disfunction B12 deficiency
- B12 associated with IF vs B12 alone
- If radio labled B12 found in feces when IF is co-administered then pernicious anemia
- If B12 not found regardless of IF then damage to distal ileum
-
B12 oral administration
- Cyanocobalamin
- hydroxocobalamin
-
Folic Acid
- Folate Oral administration
- good absorption
-
Leucovorin
- folinic acid
- skips folate reductase processing
- Prophylaxis of methotrexate (anti-cancer by anti folate reductase and cell division) toxicity
- --Leucovorin rescue - brings cell division back from methotrexate therapy
- Potientiation of 50fluorouracil therapy
- --enhance anti-cancer toxicity
-
Recombinant human EPO
- Epoetin beta >Darbepoetin alpha > Epoetin alfa
- epoetin not approved by FDA
- Darbepoetin alfa 1 dose/ week
- Epoetin alfa 3 dose/week
- often used for chronic renal disease secondary anemia
- take with folate and Fe
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