Anti-protozoal

• USED:
• prophylactic & sporozoite suppressive of P.falciparum
• P. vivax acute attacks

w/ atovaquone for chloroquine resistant falciparum

• USED:
• latent form of P. vivax & P. ovale

CONTRA: G6PD deficiency

• chloroquine
• quinine
• quinidine
• mefloquine
• doxycycline
• artemisinin

• Prophylaxis & treatment:
• chloroquine & phosphate

Prophylaxis: mefloquine/ doxycycline

• TX: quinidine gluconate
• pyrimethamine sulfadixoxide

• TX: quinidine gluconate & antifolate
• artesunate

TX: chloroquine phosphate

• chloroquine phosphate
• primaquine phosphate

USED: P. vivax, ovale, uncomplicated falciparum in the intraerythrocytic form

MOA: inhibits Haem polymerization

Resistance: transporter & efflux pump

• *** Safe in pregnancy
• *** P. vivax resistance

Used: gametocidal for P. vivax & malariae

MOA: inhibit Haem polymerization

Resistance: pfmdr1

Toxicity: tinnitus, visual, N/V, hypoglycemia, thrombocytopenia (heart toxic)

CONTRA: pregnancy

Pyrimethamine and sulfadioxine combo

MOA: inhibit parasite DHF reductase

Used: entamoeba histolytica & intestinal flagellates

MOA: prodrug that deprives anaerobes of reducing equivalents

A/E : metallic aftertaste

USED: acute Chagas disease

MOA: intracellular reduction -> auto-oxidation

A/E: seizures and polyneuritis

USED: visceral leishmaniasis