List the functions of the lymphatic system and the immune system?
- a. transports protein from interstial space > blood
- b. transports fat from sm. intestine > blood
- c. resistance: ability to remain unaffected by noxious agents
Define lymphoid organ?
List the lymphoid organs and their functions?
- a. thymus- T cells mature here
- b. spleen- filters blood
- c. lymph nodes- filters lymph
List the lymphoid locations?
- a. thymus- mediastinum > deep to sternum
- b. spleen- LUQ > between stomach and diaphragm
- c. lymph nodes- along lymphocytes
ability to remain unaffected by noxious agents
Define nonspecific resistance?
general fact (protect against any pathogen)
Define specific resistance?
destruction of specific target
List the factors that contribute to nonspecific resistance?
- a. physical barriers: skin cavity lining
- b. mechanical factors: body fluids, resp. celia, peristalsis
- c. chemical factors:
- 1. Ph (skin, genetital tract, stomach)
- 2. interferon- protein produced by virus infected cells (protect uninfected cells)
- d. inflammation: tissue reaction to injury
Define inflammation and identify its purpose?
- tissue reaction d/t injury
- destroys, dilutes, contains injurious agents and paves way for repair
(Ag) molecule that causes an immune response
(Ab) molecule produced in response to an Ag, combines with and destroys the Ag containing structure
List the immune system cells and provide their functions?
- a. macrophage: phagocytizes, processes, and presents Ag on its surface
- b. B lymphocyte:
- 1. plasma cell
- 2. memory
- c. T lymphocyte:
- 1. cytotoxic- kills virus infected cells
- 2. suppressor
- 3. helper
- 4. memory
Outline the 2 types of cell interactions involved in immune response regulation?
- a. indirect: via interleukins
- b. direct:
- 1. foreign antigen
- 2. human leukocyte antigen
Identify what mediates hemoral immunity?
- 1. IgM
- 2. IgG
- 3. IgA
Identify what mediates cell mediated immunity (CMI)?
cytotoxic T cells
Characterize IgM, IgG, IgA?
- IgM : first in blood
- IgG: second in blood > #1 type > crosses placenta
- IgA: secretions
Contrast the primary and secondary responses regarding onset, duration, and intensity?
- primary: first
- secondary: d/t memory > faster onset, more intense, longer
The secondary response is the result of what immune system characteristic?
Define naturally acquired?
d/t natural events
Define naturally passive?
- subject's immune system doesn't participate
- ex: transfer of material Ab via breastmilk or placenta to child
Define naturally active?
- subject's immune system responds to normal Ag exposure
- ex: cold virus immunity d/t past exposure
Define artificially acquired?
Define artificially passive?
- administration of pre-formed Ab
- ex: after HAV exposure to taco bell
Define artificially active?
- subject's immune system responds to admin. of Ag
- ex: vaccines (HAV, measles, influenza)