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List the functions of the lymphatic system and the immune system?
- a. transports protein from interstial space > blood
- b. transports fat from sm. intestine > blood
- c. resistance: ability to remain unaffected by noxious agents
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Define lymphoid organ?
lymphocytes (immunity)
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List the lymphoid organs and their functions?
- a. thymus- T cells mature here
- b. spleen- filters blood
- c. lymph nodes- filters lymph
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List the lymphoid locations?
- a. thymus- mediastinum > deep to sternum
- b. spleen- LUQ > between stomach and diaphragm
- c. lymph nodes- along lymphocytes
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Define resistance?
ability to remain unaffected by noxious agents
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Define nonspecific resistance?
general fact (protect against any pathogen)
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Define specific resistance?
destruction of specific target
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List the factors that contribute to nonspecific resistance?
- a. physical barriers: skin cavity lining
- b. mechanical factors: body fluids, resp. celia, peristalsis
- c. chemical factors:
- 1. Ph (skin, genetital tract, stomach)
- 2. interferon- protein produced by virus infected cells (protect uninfected cells)
- d. inflammation: tissue reaction to injury
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Define inflammation and identify its purpose?
- tissue reaction d/t injury
- destroys, dilutes, contains injurious agents and paves way for repair
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Define antigen?
(Ag) molecule that causes an immune response
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Define antibody?
(Ab) molecule produced in response to an Ag, combines with and destroys the Ag containing structure
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List the immune system cells and provide their functions?
- a. macrophage: phagocytizes, processes, and presents Ag on its surface
- b. B lymphocyte:
- 1. plasma cell
- 2. memory
- c. T lymphocyte:
- 1. cytotoxic- kills virus infected cells
- 2. suppressor
- 3. helper
- 4. memory
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Outline the 2 types of cell interactions involved in immune response regulation?
- a. indirect: via interleukins
- b. direct:
- 1. foreign antigen
- 2. human leukocyte antigen
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Identify what mediates hemoral immunity?
- immunoglobins
- 1. IgM
- 2. IgG
- 3. IgA
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Identify what mediates cell mediated immunity (CMI)?
cytotoxic T cells
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Define immunoglobulin?
antibodies
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Characterize IgM, IgG, IgA?
- IgM : first in blood
- IgG: second in blood > #1 type > crosses placenta
- IgA: secretions
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Contrast the primary and secondary responses regarding onset, duration, and intensity?
- primary: first
- secondary: d/t memory > faster onset, more intense, longer
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The secondary response is the result of what immune system characteristic?
memory
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Define naturally acquired?
d/t natural events
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Define naturally passive?
- subject's immune system doesn't participate
- ex: transfer of material Ab via breastmilk or placenta to child
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Define naturally active?
- subject's immune system responds to normal Ag exposure
- ex: cold virus immunity d/t past exposure
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Define artificially acquired?
d/t medecine
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Define artificially passive?
- administration of pre-formed Ab
- ex: after HAV exposure to taco bell
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Define artificially active?
- subject's immune system responds to admin. of Ag
- ex: vaccines (HAV, measles, influenza)
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