-
IFN-I
- DC -> T cell
- Initiation of adaptive response (signal 3)
- antiviral
-
IL-1
- Monos, Macs -> T cells, Hepatocytes
- T Cell activation
- Fever
-
IL-2
- T Cells -> T Cells
- T Cell proliferation
- T Reg maintenance
-
IL-3
- T Cells, Thymic Epi cells -> HSC, NK, LAK cells
- Works w/ IL-5, GM-CSF in hematopoiesis, B Cell development
-
IL-4
- TH2 -> B cells
- Ig class switching (G and A)
- B Cell proliferation
-
IL-5
- Th2, Masts -> Eos, B Cells
- Eos hematopoiesis
- Increase IgG1
-
IL-6
- T Cells, Macs, Endos -> B Cells, HSCs, hepatocytes
- B Cell growth, differentiation, ig secretion
- Acute phase response proteins
- Inflammation
-
IL-7
- Bone Marrow, Thymic Stroma -> Pre-B, T
- Proliferation
- T Cell maintenance
-
IL-10
- TH2, B Cells, Macs -> TH1, NK Macs
- Decrease APC function
- Decrease TH1 cytokines
-
IL-12
- DC -> T cells
- Initiation of adaptive immune response
- TH1 polarization
-
IL-15
Maintains T memory cells
-
-
IFN-Gamma
- TH, CTL -> CTL, NK, Macs
- Increase MHC expression
- Increase APC
- Decrease pathogen
-
GM-CSF
- Monos, T Cells -> Myelomonocytes, DCs
- Stimulates marrow to produce more granulocytes, monos
-
G-CSF
- Fibroblasts, Mons -> Granulocyte precurses
- Marrow increases PMNs
-
TGF-Beta
- CD4s, Monos -> T Cells, Dcs
- Decrease mono activation
- Decrease cell growth
- Increase Treg, T17
-
TNF-alpha
- Macs, NK, T Cells -> Many
- Inflammation
- Endothelial Cell activation
- Acute phase response
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