Path Pancreas

  1. Ectopic Pancreatic tissue could be present in what locations?
    • ileum
    • duodenum
    • jejunum
    • stomach
    • meckels diverticulum
  2. What is the basic pathology of acute pancreatitis?
    • edema
    • fat necrosis
    • saponification
  3. What are the causes of acute pancreatitis?
    • Gallstones
    • Ethanol
    • Trauma
    • Scorpion Sting
    • Mumps
    • Autoimmune
    • Steroids
    • Hypercalcemia/hyperlipidemia
    • ERCP-endoscopic retrograde cholangiopancreatography
    • Drugs:sulfa
  4. Risk factor for pancreatic adenocarcinoma?
    • smoking
    • pancreatitis---etoh induced
  5. Hep B antigen is associated with what vasculitis?
    Poly arteritis nodosa
  6. 3 Infectious causes of Acute Pancreatitis?
    • mumps
    • Coxsackie
    • Mycoplasma Pneumoniae
  7. What is the relationship between the calcium level in blood and pancreatitis?
    hypercalcemia--activate autolytic enzymes which leads to fat necrosis which consumes calium leading to HYPOCALCEMIA
  8. What is a bad prognosis sign for acute pancreatitis?
  9. Trosussae Syndrome?
    • migratory thrombophlebitis
    • Procoagulopathic state bc of Pancreatic Adenocarcinoma
  10. Courvoisier's sign?
    obstructive jaundice with palpapble gallbladder
  11. Hemorrhagic pancreatitis can lead to what severe complication?
  12. Activation of what enzyme triggers autodigestion of pancreas in acute pancreatitis?
  13. What marker is more specific for acute pancreatits?
    • Lipase appears later but more specific
    • Amylase appears early
  14. How is ARDS developed from Acute Pancreatitis?
    acture pancreatits-->shock--->ARDS bc of increased vessel permeability
  15. What are the differentials for acute abdomen?
    • perforated peptic ulcer
    • cholangitis
    • cholecystitis
    • perforated diverticulitis
  16. What is the difference between acute and chronic pancreatitis?
    chronic is just like + fibrosis
  17. CYst?
    dilated fluid cavity covered by epithelium
  18. Pseudocyst?
    dilated fluid filled cavity lined by fibrotic tissue
  19. What syndrome gives pancreatic/acini cysts?
    Von Hippel Disease
  20. When do Pancreatic Pseudocysts form?
    after an acute case of pancreatitis
  21. WHich pancreatic cystoadenomas are benign?
    Serous cystoadenoma
  22. What is the Oncogene mutation associated with Pancreatic adenocarcinoma?
    • K-Ras
    • but also
    • p53
    • p16
    • SMAD4
  23. Pancreatic cancer in the head or neck of pancreas would present how?
    Pruritis, jaundice, pale stools, dark urine, steatorrhea, Fat soluble vitamin deficiency
  24. Whats responsible for desmoplasia?
    body's immune response to neoplasm
  25. What kind of neoplasm is pancreatic cancer?
    ductal carcinoadenoma
  26. Two markers in Pancreatic adenocarcinoma?
    • CEA
    • CA-19-9
  27. CA12-5
    • Ca12-5--ovarian
    • CA19-9-pancreatic
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Path Pancreas
Path Pancreas